Evidence map›Paper›PMID 42409948›Full record

ArticleNature immunology2026

Mapping self-associating chromatin hubs identifies Id proteins as key determinants of exhausted CD8

Wei Hu, Qing Chen, Shaoqi Zhu, Shengen Shawn Hu, Haibo Yu, Vanita Patel, Ying Wang, Vladimir P Badovinac, Yi Zhang, Chongzhi Zang and 2 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Wei Hu *Center for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Qing Chen *Department of Physics, The George Washington University, Washington, DC, USA.ORCID http://orcid.org/0000-0002-7360-5700
Shaoqi Zhu *Department of Physics, The George Washington University, Washington, DC, USA.
Shengen Shawn Hu *Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-9691-7344
Haibo YuCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Vanita PatelCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Ying WangCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.ORCID http://orcid.org/0000-0001-7958-8182
Vladimir P BadovinacDepartment of Pathology, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0003-3180-2439
Yi ZhangCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Chongzhi ZangDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA. zang@virginia.edu.ORCID http://orcid.org/0000-0003-4812-3627
Weiqun PengDepartment of Physics, The George Washington University, Washington, DC, USA. wpeng@gwu.edu.ORCID http://orcid.org/0000-0001-5521-9091
Hai-Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA. haihui.xue@hmh-cdi.org.ORCID http://orcid.org/0000-0002-9163-7669

Funding

Tcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4M
Tcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6M
TLE transcription cofactors in anti-viral and anti-tumor immunityR01AI187349 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI XUE, HAI-HUI · 2025 to 2025
$3.4M
Ezh2 regulates follicular helper T cell differentiationR01AI139874 · NIAID · UNIVERSITY OF IOWA · PI PENG, WEIQUN, XUE, HAI-HUI · 2018 to 2022
$2.4M
ID3 regulation of tissue-infiltrating T cells mediating graft-versus-host disease and leukemia rejectionR01CA290808 · NCI · HACKENSACK UNIVERSITY MEDICAL CENTER · PI Hai-Hui Xue, YI ZHANG · 2024 to 2026
$2.2M
BLRD VA I01 BX005771NCI NIH HHS R01 CA290808NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI139874NIAID NIH HHS R01 AI187349U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA290808U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI112579U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI114543U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI121080U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI139874U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI187349U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI191414U.S. Department of Veterans Affairs (Department of Veterans Affairs) BX005771
6 · The paper itself

Abstract

Within days of exposure to chronic viral infections, activated CD8

Indexed as

CD8-Positive T-LymphocytesChromatinInhibitor of Differentiation Protein 2Inhibitor of Differentiation ProteinsT-Cell ExhaustionAnimalsCell DifferentiationChromatin Assembly and DisassemblyCore Binding Factor Alpha 3 SubunitHepatocyte Nuclear Factor 1-alphaLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutChromatinCore Binding Factor Alpha 3 SubunitHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseIdb2 protein, mouseIdb3 protein, mouseInhibitor of Differentiation Protein 2Inhibitor of Differentiation Proteins

Identifiers

PMID42409948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.