Evidence map›Paper›PMID 42409814›Full record

ArticleNature communications2026

Fibronectin-induced overactivation of α

Iván Alarcón-Ruiz, María Jesús Ruiz-Rodríguez, Sara Martínez-Martínez, Marta Toral, Noelia Martín-Bermejo, Sergio Mateos-García, Teresa Gil-Ruiz, Elías Herrero-Galán, María José Méndez-Olivares, Dolores López-Maderuelo and 14 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Iván Alarcón-RuizGene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID 0000-0002-1372-8469
María Jesús Ruiz-Rodríguez *Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID 0000-0002-9317-8646
Sara Martínez-Martínez *Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Marta Toral *Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Noelia Martín-BermejoGene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Sergio Mateos-GarcíaGene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID 0000-0002-3923-7609
Teresa Gil-RuizTissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.
Elías Herrero-GalánMolecular Mechanics of the Cardiovascular System, CNIC, Madrid, Spain.ORCID 0000-0003-1916-6185
María José Méndez-OlivaresGene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Dolores López-MaderueloGene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID 0000-0002-1818-3576
Carolina Gutiérrez-MartínezTissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.ORCID 0000-0003-2111-8369
Cristina ClementeTissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.
Alejandro Clemente-MantecaMolecular Mechanics of the Cardiovascular System, CNIC, Madrid, Spain.ORCID 0000-0001-9385-4897
Alberto H-AlcántaraTissue & Organ Homeostasis Program, Centro de Biologia Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.ORCID 0000-0001-7946-9861
Andrea GualaCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.ORCID 0000-0002-5006-8164
Arturo EvangelistaTeknon Medical Centre-Quironsalud, Heart Institute, Barcelona, Spain.
Gisela Teixido-TuraCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.ORCID 0000-0003-4714-2420
Diego Rodríguez-PuyolDepartment of Medicine, Universidad de Alcalá de Henares & Nephrology Department, Hospital Príncipe de Asturias, Alcalá de Henares; Instituto Ramon y Cajal de Investigación Sanitaria (IRYCIS), Fundación Renal Iñigo Álvarez de Toledo (FRIAT) & RICOR from Instituto de Salud Carlos III and NOVELREN from Comunidad de Madrid, Madrid, Spain.
Juan Francisco NistalCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.ORCID 0000-0002-4152-7621
Jorge Alegre-CebolladaCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.ORCID 0000-0003-0542-0170
Jesús VázquezCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.ORCID 0000-0003-1461-5092
Juan DuarteCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.ORCID 0000-0002-9153-5857
Juan Miguel RedondoGene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. jmredondo@cbm.csic.es.
Miguel R CampaneroCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. mcampanero@cbm.csic.es.ORCID 0000-0003-1410-8621

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thoracic aortic aneurysms and dissections (TAAD), a life-threatening complication of Marfan syndrome (MFS), lack curative therapies. Our previous studies revealed that versican accumulation drives MFS aortopathy through AKT-NO pathway overactivation, but the upstream mechanisms remained unclear. Here, we show that versican-driven fibronectin (FN) accumulation activates an α

Indexed as

Aortic Aneurysm, ThoracicFibronectinsIntegrin alphaVbeta3Marfan SyndromeProtein Serine-Threonine KinasesAnimalsDisease Models, AnimalDissection, Thoracic AortaFemaleHumansMaleMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPyruvate Dehydrogenase Acetyl-Transferring KinaseFibronectinsIntegrin alphaVbeta3PDK1 protein, humanPdk1 protein, mousePhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktPyruvate Dehydrogenase Acetyl-Transferring KinaseScaffold Protein ILK

Identifiers

PMID42409814
PMCPMC13338287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.