Evidence map›Paper›PMID 42409784›Full record

Observational studyRenal failure2026

Urinary neutrophil gelatinase-associated lipocalin: a key biomarker for differentiating acute kidney injury and predicting short-term mortality in liver cirrhosis patients.

Pooja Basthi Mohan, Shankar Prasad Nagaraju, Balaji Musunuri, Ganesh Bhat, Ravindra Prabhu, Ravindra Maradi, Shiran Shetty

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pooja Basthi MohanDepartment of Gastroenterology and Hepatology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID 0000-0001-7918-7450
Shankar Prasad NagarajuDepartment of Nephrology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal Karnataka, India.
Balaji MusunuriDepartment of Gastroenterology and Hepatology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Ganesh BhatDepartment of Gastroenterology and Hepatology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Ravindra PrabhuDepartment of Nephrology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal Karnataka, India.ORCID 0000-0002-5980-7197
Ravindra MaradiDepartment of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Shiran ShettyDepartment of Gastroenterology and Hepatology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundurinary neutrophil gelatinase-associated lipocalin (uNGAL) has emerged as a promising biomarker in clinical settings for the differential diagnosis of acute kidney injury (AKI) in chronic liver disease (CLD). This prospective study aims to evaluate the efficiency of uNGAL in the differential diagnosis of AKI among patients with CLD and in predicting short-term mortality in this population.

methodsThis prospective observational study was conducted from September 2021 to March 2024 at Kasturba Medical College, Manipal, among patients with AKI and CLD. The study was initiated after obtaining institutional ethics committee approval. Demographic and clinical data, including urine samples for NGAL analysis, were collected. Patients were followed for 90 days to record clinical outcomes.

conclusionThis study shows that uNGAL distinguishes HRS from ATN and serves as a valuable predictor of 30-day and 90-day mortality. Additionally, higher levels of ALT, MELD-Na score, and uNGAL were identified as independent risk factors for mortality.

Indexed as

Acute Kidney InjuryHepatorenal SyndromeLipocalin-2Liver CirrhosisAdultAgedBiomarkersDiagnosis, DifferentialFemaleHumansKidney Tubular Necrosis, AcuteMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesBiomarkersLCN2 protein, humanLipocalin-2acute kidney injurybiomarkerschronic liver diseasehepatorenal syndromeneutrophil gelatinase-associated lipocalinUrinary NGAL

Identifiers

PMID42409784
PMCPMC13348107

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.