Evidence map›Paper›PMID 42409678›Full record

ReviewTrends in neurosciences2026

Brain rhythms of depression: A predictive processing perspective.

Andreas Strube, Diego A Pizzagalli

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andreas StrubeDepartment of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany; Center for Depression, Anxiety and Stress Research, Department of Psychiatry, McLean Hospital, Harvard Medical School, Boston, MA, USA; Einstein Center for Youth Mental Health (ECYM), Berlin, Germany. Electronic address: mail@andreasstrube.de.
Diego A PizzagalliCenter for Depression, Anxiety and Stress Research, Department of Psychiatry, McLean Hospital, Harvard Medical School, Boston, MA, USA; Noel Drury, M.D. Institute for Translational Depression Discoveries, Departments of Psychiatry and Human Behavior, Neurobiology and Behavior, and Biomedical Engineering, University of California, Irvine, CA, USA. Electronic address: dpizzaga@hs.uci.edu.

Funding

Project 4_Bruchas : Circuit-level Approaches for Dissecting Approach/Avoidance Behaviors Mediated by Nociceptin Systems in MiceP50MH119467 · NIMH · MCLEAN HOSPITAL · PI FRANK, MICHAEL J. · 2020 to 2024
$15.9M
Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
Early Life Stress and Depression: Molecular and Functional Imaging ApproachesR01MH095809 · NIMH · MCLEAN HOSPITAL · PI DU, FEI, PIZZAGALLI, DIEGO A · 2012 to 2024
$6.4M
NIMH NIH HHS P50 MH119467NIMH NIH HHS R01 MH095809NIMH NIH HHS R37 MH068376Wellcome Trust
6 · The paper itself

Abstract

Depression is marked by anhedonia, social withdrawal, and a diminished capacity to learn from positive experiences-features that can be framed within predictive processing. Here, we review findings from human electroencephalography (EEG) that, owing to its temporal resolution, can illuminate the moment-to-moment dynamics of inference in depression. Across evoked, oscillatory, and aperiodic measures, incoming information appears to be registered yet may carry insufficient precision to revise higher-level beliefs about the self and the world. This imbalance may favour model maintenance over flexibility, with rumination as one possible subjective correlate of relative state stability. Together, these findings motivate inference phenotypes as a complementary lens on depression and yield testable predictions for EEG-guided stratification and mechanistically targeted intervention.

Indexed as

BrainBrain WavesDepressionAnhedoniaAnimalsElectroencephalographyHumansanhedoniabelief updatingcomputational psychiatryEEGreward processingrumination

Identifiers

PMID42409678
PMCPMC13344164

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.