Evidence map›Paper›PMID 42409615›Full record

ArticleBritish journal of haematology2026

Plasma metabolomics profile alterations in the onset and progression of paediatric immune thrombocytopenia.

Tong Zou, Juntao Ouyang, Zheyan Lin, Yuncui Yu, Yu Hu, Jingyao Ma, Hui Chen, Tianyou Wang, Runhui Wu, Zhenping Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tong ZouCell and Gene Therapy Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0000-0002-8937-8725
Juntao OuyangCell and Gene Therapy Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Zheyan LinCell and Gene Therapy Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Yuncui YuClinical Research Center, Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0000-0002-1559-9752
Yu HuHematology Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Jingyao MaHematology Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0000-0003-3737-0876
Hui ChenCell and Gene Therapy Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Tianyou WangBeijing Key Laboratory of Pediatric Hematology Oncology; Ministry of Education Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0000-0003-1355-0661
Runhui WuHematology Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Zhenping ChenCell and Gene Therapy Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Funding

Beijing Natural Science Foundation 7232051National Natural Science Foundation of China 82570179
6 · The paper itself

Abstract

Immune thrombocytopenia (ITP) is an autoimmune disorder, characterized by immune-mediated platelet destruction and decreased platelet production. To investigate metabolic alterations associated with paediatric ITP and disease chronicity, we performed untargeted plasma metabolomics analysis in 60 newly diagnosed ITP (nITP) patients, 39 chronic ITP (cITP) patients and 39 healthy controls (HC) from Beijing Children's Hospital between October 2020 and August 2024. A total of 30 differential metabolites were identified between ITP patients and HC, with altered tryptophan metabolism among the most significantly enriched metabolic pathways. Random forest analysis achieved an accuracy of 83.9% and a precision of 95.1%. Glycocholic acid demonstrated strong discriminatory performance, with an area under the receiver operating characteristic curve of 0.882 (95% confidence interval: 0.814-0.950). In addition, phosphatidylcholine-related metabolites and sphingolipid-related metabolites were associated with metabolic alterations observed between nITP and cITP. Overall, paediatric ITP was associated with distinct plasma metabolic alterations, particularly involving tryptophan metabolism, bile acid metabolism and lipid metabolism. These findings provide additional insights into metabolic alterations associated with paediatric ITP and disease chronicity.

Indexed as

MetabolomeMetabolomicsPurpura, Thrombocytopenic, IdiopathicAdolescentBiomarkersChildChild, PreschoolDisease ProgressionFemaleHumansMaleBiomarkersimmune thrombocytopeniamachine learningmetabolomicsplasma

Identifiers

PMID42409615
PMCPMC13570140

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.