SynthesisThe journal of obstetrics and gynaecology research2026
Maternal-to-Child-Transmission of Human Immunodeficiency Virus in Maternal Preterm Premature Rupture of the Membranes: A Systematic Review.
Synthesis in The journal of obstetrics and gynaecology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimPreterm premature rupture of membranes (PPROM) in the context of maternal human immunodeficiency virus (HIV) infection poses a significant clinical dilemma, as clinicians must balance the risks of prematurity with the risks of delaying delivery and potentially increasing the chance of mother-to-child transmission (MTCT) of HIV. This review aimed to identify the rate of MTCT in HIV-positive pregnant individuals with PPROM and assess neonatal outcomes.
methodsA systematic search strategy following PRISMA guidelines, developed by an information specialist, was applied across seven online databases from inception to 2023. Prospective and retrospective cohort studies of HIV-positive patients with PPROM in which rates of MTCT were reported were included. Case reports and case series were eligible for inclusion. Data were extracted by two independent reviewers, and meta-analysis was performed when possible.
resultsOf 312 screened articles, three studies from the USA and one from South Africa met inclusion criteria, representing 58 pregnancies. The crude rate of MTCT was 6.9% (n = 4). Unadjusted logistic regression in two studies revealed no association between MTCT and antiretroviral use, CD4 count, gestational age, or length of PPROM. There was, however, a trend toward increased MTCT risk with elevated viral load (p = 0.09) or spontaneous vaginal delivery (p = 0.06).
conclusionsThe crude rate of MTCT of HIV in women with PPROM was approximately 6.9%, albeit in a heterogeneous population with variable antiretroviral use. More recent data reflecting contemporary HIV management are needed to better inform counseling and decision making in this challenging clinical scenario.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.