Evidence map›Paper›PMID 42409341›Full record

ArticleMagnetic resonance imaging2026

Association between CMR-derived pulmonary artery pulse wave velocity and pulmonary risk factors: the multi-ethnic study of atherosclerosis COPD study.

Roy Huurman, Eric Xie, Yoshiaki Ohyama, Chikara Noda, So-Yeon Lim, Colin O Wu, Eliseo Guallar, Martin R Prince, R Graham Barr, David A Bluemke and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roy HuurmanErasmus University Medical Center, Rotterdam, the Netherlands.
Eric XieJohns Hopkins University, MD, USA.
Yoshiaki OhyamaJohns Hopkins University, MD, USA.
Chikara NodaShowa University, Tokyo, Japan.
So-Yeon LimJohns Hopkins University, MD, USA.
Colin O WuNational Institutes of Health, MD, USA.
Eliseo GuallarJohns Hopkins University, MD, USA.
Martin R PrinceCornell University, NY, USA; Columbia University, NY, USA.
R Graham BarrColumbia University, NY, USA.
David A BluemkeUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Joao A C LimaJohns Hopkins University, MD, USA.
Bharath Ambale-VenkateshJohns Hopkins University, MD, USA. Electronic address: bambale1@jhmi.edu.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Fish Oil Intake, Biomarkers and Change in Lung FunctionR01HL075476 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARR, R GRAHAM · 2004 to 2008
$2.8M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
$443k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095168 · HC · JOHNS HOPKINS UNIVERSITY · PI BLUEMKE, DAVID A. · 1999 to 2000
$375k
NCRR NIH HHS UL1 RR024156NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL075476NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081
6 · The paper itself

Abstract

purposePulse wave velocity (PWV) is a quantitative marker of arterial stiffness which is widely validated in the systemic circulation. Pulmonary artery (PA) stiffness, as measured by PWV, and its associations with disease, risk factors, and outcomes are largely unestablished. We aimed to assess the association of PA PWV with smoking history.

methodsThis prospective cohort study was conducted among participants enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) COPD who received cardiac magnetic resonance (CMR). 2-D phase contrast images were acquired to assess flow. PA PWV was assessed using validated semi-automated software for the main, right, and left PA by a single reader. Non-parametric, skewed data were log-transformed as appropriate and univariable, and multivariable linear regression models were used to analyze association of PA PWV and to demographic factors and cardiopulmonary risk.

resultsA total of 166 participants were included in this study after excluding for artifacts or incomplete scans. Participants were 65% male, average age 68 ± 7 years, smoked an average of 34 ± 20 pack-years, and 36% had COPD. A unit increase in pack-year was associated with a higher log average PA PWV of 0.007 (p < 0.01). This association persisted after adjustment for demographics, vascular risk factors, COPD stage and ABI. PA PWV was not associated with COPD status.

conclusionsWe demonstrated that a severe smoking history was independently associated with a greater PA PWV. Our study advances the understanding of the mechanisms of cardiopulmonary risk factors and underscores the potential clinical applicability of PA PWV measurement for early disease detection.

Indexed as

AtherosclerosisMagnetic Resonance ImagingPulmonary ArteryPulmonary Disease, Chronic ObstructivePulse Wave AnalysisAgedCohort StudiesEthnicityFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsSmokingVascular StiffnessCOPDPulse wave velocitySmoking

Identifiers

PMID42409341
PMCPMC13552539

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.