Evidence map›Paper›PMID 42409282›Full record

ArticleClinical medicine (London, England)2026

Prognostic value of C-reactive protein to albumin ratio (CAR) for mortality in older adults with sepsis: Cohort study.

O Jiménez-Zarazúa, B I Tolentino-Pérez, L N Vélez-Ramírez, J D Mondragón

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Article in Clinical medicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

O Jiménez-ZarazúaHospital General Zona 21 IMSS, Department of Internal Medicine, León, Guanajuato, Mexico; Universidad de Guanajuato, Department of Medicine and Nutrition, León, Guanajuato, Mexico.
B I Tolentino-PérezUniversidad de Guanajuato, Department of Medicine and Nutrition, León, Guanajuato, Mexico; Hospital General Zona 21 IMSS, Department of Geriatrics, León, Guanajuato, Mexico.
L N Vélez-RamírezUniversidad de Guanajuato, Department of Medicine and Nutrition, León, Guanajuato, Mexico; Hospital General León, Department of Radiology, León, Guanajuato, Mexico.
J D MondragónUniversity of Groningen, University Medical Center Groningen, Department of Neurology, Groningen, the Netherlands; Universidad Nacional Autónoma de México, Instituto de Neurobiología, Departamento de Neurobiología Conductual y Cognitiva, Laboratorio de Psicofisiología, Querétaro, Mexico; San Diego State University, Department of Psychology, Life-Span Human Senses Lab, San Diego, CA, USA. Electronic address: jdmondragon@sdsu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectiveTo evaluate the prognostic value of the C-reactive protein/albumin (CAR) for mortality in older adults with sepsis. DESIGN AND

settingProspective observational cohort study conducted at General Hospital Zone No. 21, León, Guanajuato, Mexico (Nov 2023-Aug 2025).

participantsConsecutive patients aged >60 years with Sepsis-3-defined sepsis or septic shock, excluding those with prior ICU care, transfers, malignancies, cirrhosis, autoimmune disease, or non-septic shock.

interventionsNone. The CAR and Sequential Organ Failure Assessment (SOFA) scores were measured at diagnosis and 72 h.

main outcome measures28-day all-cause mortality, with predictive performance assessed via area under the ROC curve (AUC).

resultsCAR was higher in septic shock versus sepsis. In patients with sepsis, both initial (AUC = 0.867) and 72-h (AUC = 0.852) ratios predicted mortality better than SOFA (AUC = 0.786). In septic shock, SOFA was superior (AUC = 0.785 vs. 0.637). An initial ratio in the highest tertile independently predicted mortality (HR 2.88, 95% CI 1.15-5.19, p < 0.001).

conclusionsThe CAR is a strong, independent mortality predictor in older adults with sepsis, outperforming SOFA in sepsis but not in septic shock. This simple biomarker can aid early identification of high-risk patients to guide timely intervention.

Indexed as

28-day mortalityC-reactive protein/albumin ratioOlder adult sepsisPrognostic biomarkerSeptic shock

Identifiers

PMID42409282
PMCPMC13396719

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