Evidence map›Paper›PMID 42409280›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2026

Pushing the age limit: Mitral valve surgery is safe and effective in octogenarians.

Ricky Patil, Matthew Kazaleh, China Green, Jessica Woodford, Jeremy Wolverton, Matthew Romano, Steven F Bolling, Robert B Hawkins, Gorav Ailawadi

Abstract read
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In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ricky PatilDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Mich.
Matthew KazalehDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Mich.
China GreenDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Mich.
Jessica WoodfordDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Mich.
Jeremy WolvertonDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Mich.
Matthew RomanoDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Mich.
Steven F BollingDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Mich.
Robert B HawkinsDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Mich.
Gorav AilawadiDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Mich. Electronic address: ailawadi@umich.edu.

Funding

Surgeon Scientist Training in Cardiac DiseasesT32HL166113 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gorav Ailawadi, YUQING Eugene CHEN · 2023 to 2026
$1.4M
NHLBI NIH HHS T32 HL166113
6 · The paper itself

Abstract

objectiveOctogenarians represent a growing population of patients who require intervention for mitral valve disease. With the advent of transcatheter mitral approaches, the role of surgery, particularly valve repair, is under scrutiny. Comorbidity burden, poor tissue quality, and limited life expectancy have been cited as obstacles to benefiting from valve repair attempts. This study aims to capture outcomes of mitral valve surgery in octogenarians and compare outcomes of surgical valve repair and replacement.

methodsAll patients aged 80 years and older who underwent surgical mitral valve operations at a high-volume valve center were included in analysis. Analysis of all patients and subanalysis of patients with degenerative mitral regurgitation was conducted. Outcomes evaluated included operative mortality and midterm survival.

resultsBetween 2015 and 2024, a total of 221 octogenarians underwent mitral surgery, including 158 (71%) undergoing mitral valve repair and 63 (29%) who underwent replacement for any etiology. Overall operative mortality was 5% (12 out of 221) (Society of Thoracic Surgeons Predicted Risk of Mortality, 5%) and was lower following mitral repair versus replacement (3% vs 11%; P = .04). On a subanalysis of 168 patients with degenerative mitral regurgitation (141 [84%] repair, 27 [16%] replacement), operative mortality was 1.2% (2 out of 168), with no difference by procedure type. Valve repair was associated with improved midterm survival for up to 4 years postsurgery (P = .02).

conclusionsMitral surgery can be performed safely and effectively in appropriately selected octogenarians. Valve repair, when feasible, can promote improved midterm survival.

Indexed as

mitral regurgitationmitral valve repairmitral valve replacementoctogenarian

Identifiers

PMID42409280
PMCPMC13636366

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.