Evidence map›Paper›PMID 42409205›Full record

Observational studyThe journal of pain2026

Applying an intersectional framework to characterize chronic pain disparities one year following traumatic spinal cord injury.

Joel Fundaun, Titilola Falasinnu, Dario Pfyffer, Troy C Dildine, Melissa Kolski, Allen W Heinemann, Suzanne Tharin, Andrew C Smith, Benjamin Dirlikov, Sean Mackey and 2 more

Abstract readObservational Study
In one paragraph

Observational study in The journal of pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joel FundaunDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: jfundaun@stanford.edu.
Titilola FalasinnuDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Dario PfyfferDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Troy C DildineDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Melissa KolskiDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA; Musculoskeletal Outpatient Department, Shirley Ryan AbilityLab, Chicago, IL, USA.
Allen W HeinemannDepartment of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Center for Rehabilitation Outcomes Research, Shirley Ryan AbilityLab, Chicago, IL, USA.
Suzanne TharinDepartment of Neurosurgery, Stanford University Medical Center, Stanford, CA, USA; Division of Neurosurgery, VA, Palo Alto, CA, USA.
Andrew C SmithPhysical Therapy Program, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Colorado, Aurora, CO, USA.
Benjamin DirlikovRehabilitation Research Center, Santa Clara Valley Medical Center, San Jose, CA, USA.
Sean MackeyDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
James CrewRehabilitation Research Center, Santa Clara Valley Medical Center, San Jose, CA, USA; Department of Physical Medicine and Rehabilitation, Santa Clara Valley Medical Center, San Jose, CA, USA.
Kenneth A WeberDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Interdisciplinary Research Training in Pain and Substance Use DisordersT32DA035165 · NIDA · STANFORD UNIVERSITY · PI SEAN C MACKEY · 2013 to 2026
$7.2M
MRI-Derived Neuromuscular Signatures to Predict Surgical Response in Degenerative Cervical MyelopathyR01NS128478 · NINDS · STANFORD UNIVERSITY · PI Kenneth Arnold Weber · 2023 to 2026
$2.2M
Improving mechanistic understanding of responsiveness to spinal cord stimulation after spinal cord injuryK01HD106928 · NICHD · UNIVERSITY OF COLORADO DENVER · PI SMITH, ANDREW CRAIG · 2022 to 2025
$508k
ACL HHS 90SIMS0015NICHD NIH HHS K01 HD106928NIDA NIH HHS T32 DA035165NINDS NIH HHS R01 NS128478
6 · The paper itself

Abstract

Chronic pain affects nearly 70% of individuals following traumatic spinal cord injury (SCI) and is frequently reported as a disabling and undertreated complication. While disparities in SCI recovery are well-documented, evidence in chronic pain remains limited, with prior studies involving smaller cohorts and evaluating isolated social determinants rather than their intersectional contributions. We conducted a retrospective cohort study using the US Spinal Cord Injury Model Systems database, including 3514 adults with traumatic SCI. Exposures were race/ethnicity (non-Hispanic White, non-Hispanic Black), annual income (<$25,000 vs ≥$25,000), and education (high school or less vs higher). Outcomes were pain severity (0-10 numeric rating) and pain interference (SF-12; severe[3-4] vs minimal/moderate[0-2]). Models adjusted for demographic and injury characteristics. Intersectional analyses quantified the combined effects of multiple social disadvantages, and causal mediation analyses estimated average causal mediation effects (ACME). Non-Hispanic Black, lower-income, and lower-education participants had higher pain severity and more frequent severe pain interference than their counterparts (all p<0.0001). Non-Hispanic Black participants, low-income, low-education participants had +2.43 points (95%CI 2.06-2.79) higher pain severity and 2.96-fold (95%CI 2.15-4.07) higher odds of severe pain interference than non-Hispanic White, higher-income, higher-education participants (q<0.0001). Mobility scores, days out-of-the-house, private health insurance, and perceived health status significantly mediated disparities in pain severity (ACME 0.158-0.312) and pain interference (ACME 0.017-0.043; all q<0.001). Chronic pain after traumatic SCI disproportionately affects socially disadvantaged groups. These findings highlight intersectional disparities and identify modifiable mediators as targets for interventions to reduce inequitable pain outcomes following traumatic SCI. PERSPECTIVE: This retrospective multicenter cohort study quantified intersectional disparities in chronic pain one year following spinal cord injury and characterized modifiable individual and structural mediators that account for these inequities.

Indexed as

Chronic PainHealth Status DisparitiesSocial Determinants of HealthSpinal Cord InjuriesAdultBlack or African AmericanEducational StatusFemaleHumansMaleMiddle AgedRetrospective StudiesSocioeconomic Disparities in HealthWhiteChronic painHealth inequitiesMediationSocial determinants of healthSpinal cord injury

Identifiers

PMID42409205
PMCPMC13575930

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.