Evidence map›Paper›PMID 42407391›Full record

ArticleCell calcium2026

Calorie restriction modulates beta cell IP

Johannes Pfabe, Amanda Cambraia, Prasanna K Dadi, Melanie Cutler, Cristiane Dos Santos, Christopher Acree, Aliyah Habashy, Guy Perkins, Mark H Ellisman, David A Jacobson and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cell calcium, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Johannes PfabeInstitute of Physiology, Center for Physiology and Pharmacology and Comprehensive Center for AI in Medicine, Medical University of Vienna, 1090, Austria.
Amanda CambraiaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, 37211, USA.
Prasanna K DadiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, 37211, USA.
Melanie CutlerDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, 37211, USA.
Cristiane Dos SantosDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, 37211, USA.
Christopher AcreeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, 37211, USA.
Aliyah HabashyDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, 37211, USA.
Guy PerkinsNational Center for Imaging and Microscopy Research (NCMIR) and the Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, 92135, California, USA.
Mark H EllismanNational Center for Imaging and Microscopy Research (NCMIR) and the Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, 92135, California, USA.
David A JacobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, 37211, USA; Diabetes Research and Training Center (DRTC), Vanderbilt University, Nashville, Tennessee, 37235, USA.
Marjan Slak RupnikInstitute of Physiology, Center for Physiology and Pharmacology and Comprehensive Center for AI in Medicine, Medical University of Vienna, 1090, Austria; University of Maribor, Faculty of Medicine, Institute for Physiology, Maribor, 2000, Slovenia. Electronic address: marjan.slakrupnik@meduniwien.ac.at.
Rafael Arrojo E DrigoDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, 37211, USA; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, 37235, USA; Diabetes Research and Training Center (DRTC), Vanderbilt University, Nashville, Tennessee, 37235, USA; Vanderbilt Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, 37235, USA. Electronic address: r.drigo@vanderbilt.edu.

Funding

National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination ResourceU24NS120055 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2021 to 2025
$5.4M
Molecular Mechanisms Regulating Pancreatic Delta Cell Function and DysfunctionR01DK129340 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2022 to 2026
$2.3M
Control of beta cell function and survival by RYR2-mediated calcium signalsR01DK127236 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA · 2021 to 2025
$2.2M
Secretagogue and Gi/o-GPCR signaling through the islet Na+/K+-ATPase in health and diabetesR01DK136768 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2023 to 2026
$2.0M
Designing selective TALK-1 inhibitors to reduce beta-cell dysfunction in diabetesR01DK115620 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2018 to 2021
$1.6M
Beta cell adaptation mechanisms during caloric restriction and ER stressR01DK138141 · NIDDK · VANDERBILT UNIVERSITY · PI Rafael Arrojo e Drigo · 2024 to 2026
$1.5M
NIDDK NIH HHS R01 DK115620NIDDK NIH HHS R01 DK127236NIDDK NIH HHS R01 DK129340NIDDK NIH HHS R01 DK136768NIDDK NIH HHS R01 DK138141NINDS NIH HHS U24 NS120055
6 · The paper itself

Abstract

Calorie restriction (CR) promotes beta cell longevity by regulating cell identity, organelle and protein homeostasis, and metabolism pathways. CR beta cells have higher cAMP levels and mitochondria with an elevated potential to generate ATP. However, CR beta cells have reduced insulin secretion due to increased peripheral insulin sensitivity. How CR impacts beta cell Ca²⁺ homeostasis to regulate beta cell insulin release remains unknown. We investigated this question using acute pancreatic tissue slices prepared from ad-libitum (AL) or CR mice loaded with a low affinity Ca²⁺ indicator and recorded cytosolic Ca²⁺ gradients with fast confocal imaging. We exposed these slices to increasing glucose concentrations and applied our semi-automatic analysis pipeline to detect thousands of individual beta cells followed by identification of individual Ca²⁺ spiking events. We observed that elevated cAMP in CR beta cells causes fast short-amplitude Ca²⁺ oscillations that potentiate insulin release despite a largely disconnected beta cell network landscape. Using acetylcholine stimulation, we found that faster IP

Indexed as

CalciumCaloric RestrictionHomeostasisInositol 1,4,5-Trisphosphate ReceptorsInsulin-Secreting CellsAnimalsCalcium SignalingCyclic AMPEndoplasmic ReticulumGlucoseInsulinInsulin SecretionMiceCalciumCyclic AMPGlucoseInositol 1,4,5-Trisphosphate ReceptorsInsulinBeta cell calciumCalorie restrictionEndoplasmic reticulum (er)

Identifiers

PMID42407391

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.