Observational studyAnnals of internal medicine2026
Prolonged Short Sleep and Its Effect on Body Weight and Composition : A Pooled Analysis of Randomized Trials.
Observational study in Annals of internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Sleep Restriction on Cardiometabolic Risk Factors in Pre vs Postmenopausal Women
Effect of Long Term Sleep Restriction on Energy Balance
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundInsufficient sleep is associated with obesity. However, the causal effect on weight status of chronic, mildly insufficient sleep and its potential variability by gender and menopausal status remain unknown.
objectiveTo explore the effect of 6 weeks of sleep restriction (SR) of 1.5 hours per night on energy balance and body weight regulation.
designPooled analysis of 2 randomized crossover trials. (ClinicalTrials.gov: NCT02960776 and NCT02835261).
settingOutpatient intervention with inpatient and outpatient assessments.
participantsAdults (
interventionSix weeks of sustained adequate sleep (AS) and SR of 1.5 hours per night separated by a multiweek washout. MEASUREMENTS: Outcome measures included adiposity (assessed using magnetic resonance imaging), body weight, waist circumference, and energy balance behaviors and biomarkers.
resultsSleep duration was reduced by 78.4 minutes (95% CI, -83.5 to -73.3 minutes) per night with SR versus AS. Body weight (0.45 kg [CI, 0.33 to 0.57 kg]), waist circumference (0.52 cm [CI, 0.25 to 0.79 cm]), and whole-body volume (0.56 L [CI, 0.19 to 0.93 L]) were increased with SR relative to AS. Leptin levels were elevated with SR versus AS (2.03 ng/mL [CI, 0.38 to 3.68 ng/mL]). Sedentary time was increased by 17.2 minutes (CI, 11.7 to 22.7 minutes) per day with SR versus AS. LIMITATIONS: The intervention duration may have been too short to identify changes in body composition, power to evaluate individual differences was limited, and effect sizes were modest.
conclusionProlonged exposure to moderately short sleep may lead to weight gain, suggesting that weight management and cardiometabolic disease prevention programs should consider incorporating sleep strategies to promote AS. PRIMARY FUNDING SOURCE: National Institutes of Health and American Heart Association.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.