Evidence map›Paper›PMID 42406962›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Invariant nonequilibrium dynamics in gene regulation optimize information flow.

Benjamin Zoller, Alexis Bénichou, Thomas Gregor, Gašper Tkačik

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Benjamin ZollerDepartment of Stem Cell and Developmental Biology, CNRS UMR3738 Paris Cité, Institut Pasteur, Paris FR-75015, France.
Alexis BénichouInstitute of Science and Technology Austria, Klosterneuburg AT-3400, Austria.
Thomas GregorDepartment of Stem Cell and Developmental Biology, CNRS UMR3738 Paris Cité, Institut Pasteur, Paris FR-75015, France.
Gašper TkačikInstitute of Science and Technology Austria, Klosterneuburg AT-3400, Austria.ORCID 0000-0002-6699-1455

Funding

The Biophysical and Molecular Mechanisms of Reliability in DevelopmentR01GM097275 · NIGMS · PRINCETON UNIVERSITY · PI GREGOR, THOMAS · 2011 to 2024
$4.9M
Control of the 4D chromatin landscape underlying gene activity during developmentU01DK127429 · NIDDK · PRINCETON UNIVERSITY · PI GREGOR, THOMAS, LEVINE, MICHAEL STEVEN · 2020 to 2024
$3.2M
Imaging chromosome dynamics and measuring its impact on transcriptional activityU01DA047730 · NIDA · PRINCETON UNIVERSITY · PI GREGOR, THOMAS, LEVINE, MICHAEL STEVEN · 2018 to 2019
$740k
Agence Nationale de la Recherche (ANR) ANR-10-LABX73Agence Nationale de la Recherche (ANR) ANR-20-CE12-0028Agence Nationale de la Recherche (ANR) ANR-23-CE13-0021European Research Council ERC-2023-SyG 101118866HHS | National Institutes of Health (NIH) R01GM097275HHS | National Institutes of Health (NIH) U01DA047730HHS | National Institutes of Health (NIH) U01DK127429National Science Foundation (NSF) PHY-1734030NIDA NIH HHS U01 DA047730NIDDK NIH HHS U01 DK127429NIGMS NIH HHS R01 GM097275
6 · The paper itself

Abstract

Eukaryotic gene regulation relies on stochastic yet controlled promoter switching, in which genes transition between transcriptionally active and inactive states. Despite the molecular complexity of this process, recent studies have revealed a surprising invariance of the "switching correlation time" (

Indexed as

Gene Expression RegulationModels, GeneticAnimalsBayes TheoremDrosophilaDrosophila melanogasterPromoter Regions, GeneticStochastic ProcessesTranscription FactorsTranscription, GeneticTranscription Factorsinformation theoryMarkov modelspromoter switchingtranscriptional regulation

Identifiers

PMID42406962
PMCPMC13367843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.