ArticlePloS one2026
Genetics of hypertension in populations affected by the Aral Sea ecological crisis: A case-control study.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis research investigates the correlation between nine polymorphic variants and the incidence of hypertension and its clinical manifestations in the Ellikqala District in the Republic of Karakalpakstan, Uzbekistan. This district is known as one of the most challenging areas for human habitation due to its high salinity levels in the environment, which contribute to a higher prevalence of cardiovascular diseases.
methodsThis was a population-based case-control study. The study included 801 participants from the Karakalpakstan region of Uzbekistan, of which 621 were patients with essential hypertension, and the remaining 180 were the control group. Genetic analysis was conducted using multiplex qPCR with allele-specific probes. A statistical approach based on logistic regression was applied to identify their association with essential hypertension and its clinical manifestations. Logistic regression under a log-additive genetic model was used to calculate unadjusted (crude) and adjusted odds ratios and 95% confidence intervals. Stratified analyses by sex, age (<60 vs. ≥ 60 years), and BMI (<25 vs. ≥ 25 kg/m²) were performed with Bonferroni correction (k = 18 per stratification; threshold p < 2.8e-3).
resultsThe analysis revealed statistically significant associations between essential hypertension and six polymorphic variants after Bonferroni correction (k = 9, corrected threshold: p < 5.6e-3): AGT C521T (rs4762; OR = 0.12, 95% CI: 0.08-0.16, p-Bonferroni = 2.99e-50), AGT T704C (rs699; OR = 0.68, 95% CI: 0.54-0.86, p-Bonferroni = 1.1979e-2), AGTR2 G1675A (rs1403543; OR = 0.52, 95% CI: 0.42-0.64, p-Bonferroni = 4.76e-9), CYP11B2 C(-344)T (rs1799998; OR = 0.47, 95% CI: 0.36-0.60, p-Bonferroni = 8.97e-9), GNB3 C825T (rs5443; OR = 1.66, 95% CI: 1.27-2.18, p-Bonferroni = 1.368e-3), and NOS3 T(-786)C (rs2070744; OR = 0.27, 95% CI: 0.21-0.34, p-Bonferroni = 2.50e-27). NOS3 G894T (rs1799983) showed a nominally significant association prior to correction (OR = 0.68, 95% CI: 0.52-0.89; p = 5.069e-3), but did not survive Bonferroni adjustment (p-Bonferroni = 4.5621e-2) and should be interpreted with caution.
conclusionSix out of nine studied polymorphic variants were associated with essential hypertension and its clinical manifestations in the Ellikqala District in the Republic of Karakalpakstan, Uzbekistan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.