Evidence map›Paper›PMID 42406513›Full record

ArticleVirulence2026

MGF100 but not MGF300 family is a potential multigene-deleted target for ASFV attenuation and live attenuated vaccine development.

Wen Dang, Fan Xu, Yu Du, Tao Li, Huanan Liu, Zhengwang Shi, Hong Tian, Jijun He, Haixue Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wen DangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, China.
Fan XuState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, China.
Yu DuState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, China.
Tao LiState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, China.
Huanan LiuState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, China.
Zhengwang ShiState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, China.
Hong TianState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, China.
Jijun HeState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, China.
Haixue ZhengState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, China.ORCID 0000-0001-6850-1379

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever (ASF) is a highly contagious and lethal disease, but few therapeutic options are available for its treatment. Therefore, there is an urgent need for the development of safe and effective vaccines. In this regard, we described the differential effect of deletion of whole MGF100 and MGF300 families from genotype II highly virulent strains on African swine fever virus (ASFV) replication, virulence, and induction of protection. The resulting ASFV-Δ100 and ASFV-Δ300 mutants demonstrated reduced growth kinetics in vitro, with the former displaying aberrant virus morphogenesis. ASFV-Δ100 was efficiently attenuated, whereas ASFV-Δ300 retained its virulence. In the homologous lethal challenge, the two mutants achieved the same protection rate, with the former providing more protection against pathology in organs. Mechanistically, we found that ASFV-Δ100 was capable of inducing a robust innate immune response in vitro and a consistent P30 antibody response in vivo. In conclusion, the MGF100 family is a potential multigene-deleted target for ASFV live-attenuated vaccine development.

Indexed as

African Swine FeverAfrican Swine Fever VirusGene DeletionViral ProteinsViral VaccinesAnimalsAntibodies, ViralImmunity, InnateMultigene FamilySwineVaccine DevelopmentVaccines, AttenuatedVirulenceVirus ReplicationAntibodies, ViralVaccines, AttenuatedViral ProteinsViral VaccinesAfrican swine fever virusinnate immunemorphogenesismultigene family 100multigene family 300protective efficacy

Identifiers

PMID42406513
PMCPMC13349000

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.