Evidence map›Paper›PMID 42406473›Full record

ArticleJournal of the American Chemical Society2026

Alternating Current-Driven Hydrogen Isotope Labeling of Aliphatic Amines Using 1,3-Propanedithiol as an Efficient Hydrogen Atom Transfer Reagent.

Nibedita Behera, Nhu H Quach, Rajendra Maity, Dan Lehnherr, Sumei Ren, Jingwei Li, Matthew Neurock, Long Luo

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nibedita BeheraDepartment of Chemistry, University of Utah, 315 S 1400 E, Salt Lake City, Utah 84112, United States.ORCID 0000-0002-4278-0135
Nhu H QuachDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Rajendra MaityDepartment of Chemistry, University of Utah, 315 S 1400 E, Salt Lake City, Utah 84112, United States.
Dan LehnherrProcess Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID 0000-0001-8392-1208
Sumei RenProcess Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID 0000-0002-5163-0489
Jingwei LiProcess Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Matthew NeurockDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0003-1458-7837
Long LuoDepartment of Chemistry, University of Utah, 315 S 1400 E, Salt Lake City, Utah 84112, United States.ORCID 0000-0001-5771-6892

Funding

Alternating Current Electrolysis for Organic SynthesisR35GM142590 · NIGMS · WAYNE STATE UNIVERSITY · PI LUO, LONG · 2021 to 2025
$2.0M
NIGMS NIH HHS R35 GM142590
6 · The paper itself

Abstract

Hydrogen isotope exchange (HIE) plays a pivotal role in the synthesis of isotopically labeled compounds, which are widely used in the pharmaceutical industry for drug pharmacokinetic and pharmacodynamic studies. While electrochemical HIE has emerged as a powerful strategy for site-selective labeling of C-H bonds, extending its application to alkyl amine-containing drugs has been hindered by the instability of

Identifiers

PMID42406473
PMCPMC13356894

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.