Evidence map›Paper›PMID 42406463›Full record

ArticlePsychological trauma : theory, research, practice and policy2026

Slopes of symptom change early in residential treatment of veterans with posttraumatic stress disorder.

Tiffany Chou, Kevin Lynch, Keith Bredemeier, Philip Gehrman, Danielle Farabaugh, Erica Weitz, Lily Brown

Abstract read
In one paragraph

Article in Psychological trauma : theory, research, practice and policy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tiffany ChouPerelman School of Medicine, University of Pennsylvania.
Kevin LynchPerelman School of Medicine, University of Pennsylvania.
Keith BredemeierDepartment of Psychological and Brain Sciences, University of Delaware.
Philip GehrmanPerelman School of Medicine, University of Pennsylvania.
Danielle FarabaughCoatesville VA Medical Center.
Erica WeitzPerelman School of Medicine, University of Pennsylvania.
Lily BrownDepartment of Psychiatry, University of Pennsylvania.ORCID 0000-0002-0879-0110

Funding

Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Karine Dube · 2013 to 2026
$23.5M
A mechanistic trial of the neurobiology of extinction learning and intraparietal sulcus stimulationR01MH132740 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Lily A Brown · 2024 to 2026
$2.4M
Nocturnal wakefulness, cognitive control, and suicidal urges: A prospective evaluation of variance during residential treatmentR21MH123888 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BREDEMEIER, KEITH ERIC, BROWN, LILY A · 2021 to 2022
$447k
NIMH NIH HHS L30 MH117700NIMH NIH HHS P30 MH097488NIMH NIH HHS R01 MH132740NIMH NIH HHS R21 MH123888
6 · The paper itself

Abstract

objectivePosttraumatic stress disorder (PTSD) is a major public health problem that is associated with significant functional impairment. While many patients respond well to treatment, little is known about patterns of improvement, and especially not in residential treatment programs. In this study, we used intensive assessment to investigate early slopes of change in PTSD symptoms in veterans in their first 28 days of residential treatment using the PTSD Checklist. Based on emotional processing theory and the focus on reducing avoidance as a key PTSD treatment target, we hypothesized that avoidance would improve while other symptoms would remain unchanged early in treatment.

methodLinear mixed-effects multilevel modeling was used to evaluate linear slopes of symptom change.

resultsThere was statistically significant improvement on avoidance of internal cues and avoidance of external cues. In contrast, none of the other items assessed (repeated disturbing memories, repeated dreams, flashbacks, physical reactions to trauma memories, hypervigilance, startle) or the total score of the PTSD Checklist changed in 28 days after admission to residential treatment.

conclusionsThese findings show that in this group of veterans with PTSD, reduction in avoidance may precede overall symptom improvement in the first 28 days of residential treatment. Future studies should replicate these findings in other residential settings and in varying treatment modalities to better understand the impact residential treatment programs have on PTSD symptom reduction. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

Identifiers

PMID42406463
PMCPMC13410991

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.