Evidence map›Paper›PMID 42406441›Full record

ArticleAnalytical chemistry2026

Towards Cellular Resolution of Tryptic Peptides in Tissue Sections by MALDI MS Imaging: A Focus on Enzyme Application and Reproducibility.

Bastian Jahreis, Julia Kokesch-Himmelreich, Alan M Race, Andreas Römpp

Abstract read
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In one paragraph

Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bastian JahreisBioanalytical Sciences and Food Analysis, University of Bayreuth, Universitätsstrasse 30, D-95447 Bayreuth, Germany.ORCID 0009-0006-5749-2466
Julia Kokesch-HimmelreichBioanalytical Sciences and Food Analysis, University of Bayreuth, Universitätsstrasse 30, D-95447 Bayreuth, Germany.
Alan M RaceBioanalytical Sciences and Food Analysis, University of Bayreuth, Universitätsstrasse 30, D-95447 Bayreuth, Germany.
Andreas RömppBioanalytical Sciences and Food Analysis, University of Bayreuth, Universitätsstrasse 30, D-95447 Bayreuth, Germany.ORCID 0000-0001-8384-9250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bottom-up proteomics coupled with matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI imaging) is the preferred method for untargeted localization and identification of proteins in tissue. However, there are no MALDI imaging workflows that combine high lateral resolution, accurate mass detection, efficient tryptic digestion, and reproducibility. In this study, we developed a MALDI imaging workflow that enables reproducible imaging of tryptic peptides in mammalian tissue sections with high resolution in mass and space. For the first time, tryptic peptides could be imaged in tissue sections at 10 μm pixel size with high mass resolution (

Indexed as

PeptidesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTrypsinAnimalsMiceProteomicsReproducibility of ResultsPeptidesTrypsin

Identifiers

PMID42406441
PMCPMC13393080

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.