ReviewHuman cell2026
The role of FOXM1 in tumor immunology: implications for cancer treatment strategies.
Review in Human cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Forkhead box protein M1 (FOXM1) is a pivotal member of the forkhead box family of transcription factors, characterized by its marked overexpression in a wide range of human malignancies and its critical role in driving tumor progression through the regulation of cancer cell proliferation and invasion, making it an attractive target for anti-cancer therapy. However, comprehensive reviews detailing the role of FOXM1 in regulating tumor immunity are still lacking. In this review, we summarize the multiple roles of FOXM1 in regulating tumor immunity and assess its potential as a therapeutic target. FOXM1 plays a crucial role in regulating the tumor immune microenvironment by modulating immune checkpoints, influencing macrophage polarization, and affecting T cell differentiation and infiltration. Furthermore, FOXM1 also plays a regulatory role in key immune-related signaling pathways, including signal transducer and activator of transcription 1 (STAT1) and interferon stimulated gene (STING). Furthermore, the potential of targeting FOXM1 to enhance the efficacy of immunotherapies is discussed, with particular emphasis on overcoming challenges related to immune evasion, neurotoxicity, and therapeutic resistance. This review also summarizes the current landscape of FOXM1-targeted drug development and application, including small molecule inhibitors, peptide-based therapeutics, and combination treatment strategies, highlighting the promising clinical prospects of FOXM1 as a novel and multifaceted target in cancer therapy.
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Identifiers
42406290What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.