ArticleJournal of neuro-oncology2026
Serum lactate dehydrogenase is associated with the presence and extent of preoperative peritumoral edema in melanoma brain metastases.
Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPeritumoral brain edema (PTBE) is a major contributor to neurological morbidity in patients with melanoma brain metastases (BM). While serum lactate dehydrogenase (LDH) is an established systemic biomarker in metastatic melanoma, its relationship with local radiological characteristics such as PTBE remains insufficiently understood. This study aimed to investigate the association between serum LDH levels and PTBE, as well as its relationship with clinical and tumor-related parameters.
methodsWe performed a retrospective analysis of 56 consecutive patients who underwent surgical resection for melanoma BM between 2012 and 2024. Preoperative MRI was used to assess the presence and volumetric extent of PTBE. Clinical, radiological, and laboratory parameters, including serum LDH levels, MIB-1 proliferation index, tumor volume and preoperative seizures were analyzed. Associations were evaluated using univariate analyses and Spearman rank correlation. Receiver operating characteristic (ROC) curve analyses were performed to assess the discriminative ability of the variables.
resultsPreoperative PTBE was present in 71.4% of patients. Serum LDH levels were significantly higher in patients with PTBE (p < 0.001) and demonstrated a strong positive correlation with edema volume (r = 0.822, p < 0.001). In addition, LDH levels were significantly correlated with the MIB-1 proliferation index (r = 0.601, p < 0.001) and tumor volume (r = 0.584, p < 0.001) and were significantly elevated in patients presenting with preoperative seizures (p < 0.001). ROC analysis demonstrated that LDH had the highest discriminative performance (AUC 0.802, p < 0.001), with an optimal cut-off value of 179.4 U/L.
conclusionsIn this exploratory study, serum LDH was associated with both the presence and extent of PTBE and may serve as a surrogate of tumor-related biological activity. These hypothesis-generating findings warrant prospective validation before clinical implications can be drawn.
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