A non-enzymatic sensor based on rGO/Pt NPs/Fc-Tyr/POPD nanocomposite for hydrogen peroxide determination in liver cancer tissues.

Xixiang Xie, Rongping Huang, Tao Zhao, Yaru Zhang, Rongfang Wang, Xiyu Liu, Qicai Xiao, Jian He, Pan Wu, Yong Huang

Abstract read

In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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10 authors.

Xixiang XieState Key Laboratory of Targeting Oncology, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Rongping HuangState Key Laboratory of Targeting Oncology, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Tao ZhaoState Key Laboratory of Targeting Oncology, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Yaru ZhangState Key Laboratory of Targeting Oncology, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Rongfang WangState Key Laboratory of Targeting Oncology, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Xiyu LiuState Key Laboratory of Targeting Oncology, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Qicai XiaoState Key Laboratory of Targeting Oncology, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Jian HeState Key Laboratory of Targeting Oncology, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Pan WuState Key Laboratory of Targeting Oncology, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China. wupan@gxmu.edu.cn.

Yong HuangState Key Laboratory of Targeting Oncology, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, National Center for International Research of Biotargeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China. huangyong503@126.com.

Funding

Guangxi Natural Science Foundation Project 2025GXNSFBA069075the Guangxi Science and Technology Major Program AA24011005the National Natural Science Foundation of China 82072340

6 · The paper itself

Abstract

Malignant tumors remain a major global health challenge, highlighting the need for rapid and sensitive analytical tools for investigating cancer-associated oxidative stress. In this study, we developed a non-enzymatic electrochemical hydrogen peroxide (H₂O₂) sensor based on a reduced graphene oxide/platinum nanoparticle/ferrocene-tyramine/poly(o-phenylenediamine) (rGO/Pt NPs/Fc-Tyr/POPD) nanocomposite. H₂O₂, although not a tumor-specific biomarker, is an important reactive oxygen species associated with oxidative stress in cancer-related systems. The proposed sensing platform integrates the high conductivity of rGO, the electrocatalytic activity of Pt NPs, the TSA-derived Fc-Tyr deposition strategy, and the anti-interference properties of POPD. The sensor exhibited two wide linear detection ranges (5.0 µM-570 µM and 570 µM-10.5 mM), a low detection limit of 1.18 µM, and a rapid response time of less than 5 s. In addition, the sensor demonstrated satisfactory selectivity, reproducibility, and stability. Compared to previously reported rGO/Pt-based H₂O₂ sensors, the present platform introduces a TSA-derived Fc-Tyr deposition strategy to facilitate interfacial electron transfer and increase the density of redox-active species. The sensor was successfully applied to monitoring H₂O₂ changes in cultured cancer cells and ex vivo tumor tissue-derived samples under chemically stimulated oxidative conditions. These findings suggest that the proposed system may provide a useful tool for investigating oxidative-stress-associated biological processes and electrochemical H₂O₂ determination.

Indexed as

Electrochemical TechniquesHydrogen PeroxideLiver NeoplasmsMetal NanoparticlesNanocompositesBiosensing TechniquesFerrous CompoundsGraphiteHumansLimit of DetectionMetallocenesPhenylenediaminesPlatinumTyramineferroceneFerrous Compoundsgraphene oxideGraphiteHydrogen PeroxideMetallocenesPhenylenediaminesPlatinumTyramineAmperometryElectrochemical sensorHydrogen peroxideReactive oxygen speciesSignal amplificationTumor microenvironment

Identifiers

PMID42406127

DOI10.1016/j.chemosphere.2022.136633

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