Evidence map›Paper›PMID 42406112›Full record

ArticleJournal of anesthesia2026

Primary myotubes as an alternative to the calcium induced calcium release test in diagnosing malignant hyperthermia susceptibility.

Sachiko Otsuki, Keiko Mukaida, Hirotsugu Miyoshi, Kenshiro Kido, Ayako Sumii, Tsuyoshi Ikeda, Takahiro Kato, Toshimichi Yasuda, Yousuke T Horikawa, Yasuko Ichihara and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sachiko OtsukiDepartment of Anesthesiology and Critical Care, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.ORCID http://orcid.org/0000-0003-4771-9867
Keiko MukaidaDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Hirotsugu MiyoshiDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. h-miyoshi@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0002-1375-5344
Kenshiro KidoDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Ayako SumiiDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Tsuyoshi IkedaDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Takahiro KatoDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Toshimichi YasudaDepartment of Anesthesiology, Hiroshima Prefectural Rehabilitation Centre, Higashi-Hiroshima, Japan.
Yousuke T HorikawaCHOC Health Alliance, Rady Children's Health Orange County, Orange, USA.
Yasuko IchiharaDepartment of Anesthesiology, Kikkoman General Hospital, Chiba, Japan.
Yasuo M TsutsumiDepartment of Anesthesiology and Critical Care, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Funding

Japan Society for the Promotion of Science 23K08382
6 · The paper itself

Abstract

backgroundMalignant hyperthermia (MH) is caused by the dysregulation of calcium (Ca

methodsIn this retrospective study, we retrospectively analyzed Ca

resultsThe CICR test identified 76 patients as CICR-Positive and 22 patients as CICR-Negative. The EC

conclusionsMyotubes responses to caffeine and 4-CmC can be regarded as a viable alternative to the conventional CICR test; however, further validation is needed before this test supersedes the CICR.

Indexed as

Diagnostic methodMalignant hyperthermiaMyotubes

Identifiers

PMID42406112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.