Evidence map›Paper›PMID 42406081›Full record

ArticleCellular and molecular life sciences : CMLS2026

UBE2L6 promotes invasion and metastasis of triple-negative breast cancer by enhancing autophagy through STK38 ISGylation.

Liang Ji, Kang Li, Jing Feng, Jun-Hui Yin, Yu-Ting He, Wen-Jing Zhang, Zhuo-Ling Li, Zi-Hao Gu, Na-Min Yang, Yuan-Qi Qiao and 5 more

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In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Liang Ji *Department of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Kang Li *Department of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Jing FengDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Jun-Hui YinDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Yu-Ting HeDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Wen-Jing ZhangDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Zhuo-Ling LiDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Zi-Hao GuDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Na-Min YangDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Yuan-Qi QiaoDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.
Ren-Jie ChengDepartment of General Surgery, Nantong Rich Hospital Affiliated to Yangzhou University, No. 2000 XingHu Ave, Economic Economic and Technological Development Zone of Nantong, Jiangsu, 226000, China.
Min WangDepartment of General Surgery, People's Hospital of Laoling, Dezhou City, Shandong, 253600, China.
Chang LiuDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China. liuchang1997@hrbmu.edu.cn.
Xin HaiDepartment of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China. haixin@hrbmu.edu.cn.
Yi ZhouDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China. zhouyi@hrbmu.edu.cn.ORCID http://orcid.org/0000-0002-6701-3709

Funding

Chen Xiao-ping Foundation for the Development of Science and Technology of Hubei Province CXPJJH11900018-2003National Natural Science Foundation of China 81900586National Natural Science Foundation of China 82270668National Natural Science Foundation of China 82274028Natural Science Foundation of Heilongjiang Province of China JJ2024LH0246Postgraduate Research & Practice Innovation Program of Harbin Medical University YJSCX2023-64HYDScientific Research Foundation of Graduate School of Harbin Medical University: Sino Russian Special Fund 2023-KYYWF-0164the Foundation of the First Affiliated Hospital of Harbin Medical University 2023 B11the Science Fund for Distinguished Young Scholars of First Affiliated Hospital of Harbin Medical University HYD2020JQ0010
6 · The paper itself

Abstract

Although aberrant activation of autophagy is well known in triple-negative breast cancer (TNBC), its functional roles and underlying mechanisms remain largely unknown. In the present study, we found that high UBE2L6 expression was strongly associated with aggressive clinical features in TNBC. We demonstrated that UBE2L6 promoted migration, invasion, and lung metastasis of TNBC by enhancing STK38-mediated autophagy. Mechanistically, UBE2L6 stabilized STK38 by promoting its ISGylation and inhibiting its ubiquitin-proteasomal degradation. Therefore, targeting UBE2L6 and modulating the STK38 ISGylation-autophagy axis represent potential intervention points in TNBC.

Indexed as

AutophagyProtein Serine-Threonine KinasesTriple Negative Breast NeoplasmsUbiquitin-Conjugating EnzymesAnimalsCell Line, TumorCell MovementFemaleHumansLung NeoplasmsNeoplasm InvasivenessNeoplasm MetastasisProtein Serine-Threonine KinasesUBE2L6 protein, humanUbiquitin-Conjugating EnzymesAutophagyMetastasisSTK38Triple-negative breast cancerUBE2L6

Identifiers

PMID42406081
PMCPMC13620027

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.