Evidence map›Paper›PMID 42406034›Full record

ReviewAbdominal radiology (New York)2026

Multimodality staging of renal cell carcinoma-pearls & pitfalls.

Samuel J Withey, Milagros Otero-Garcia, Maria Aymerich, Alejandra Baizán-García, Carlos Carnelli, Elizabeth Robinson, Richard Hesketh, Thomas Wagner, Iztok Caglic

Abstract readReview
PubMed Publisher
In one paragraph

Review in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuel J WitheyDepartment of Radiology, Royal Marsden NHS Foundation Trust, London, United Kingdom. samuel.withey@nhs.net.ORCID https://orcid.org/0000-0002-3612-844X
Milagros Otero-GarciaDepartment of Radiology, Hospital Universitario de Vigo, Vigo, Spain.
Maria AymerichDiagnostic Imaging Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), Vigo, Spain.
Alejandra Baizán-GarcíaDepartment of Radiology, Hospital Universitario de Vigo, Vigo, Spain.
Carlos CarnelliDepartment of Radiology, Asistencial Médica del Maldonado, Punta del Este, Uruguay.
Elizabeth RobinsonDepartment of Radiology, Royal United Hospital, Bath, United Kingdom.
Richard HeskethDepartment of Radiology, Lister Hospital, Stevenage, United Kingdom.
Thomas WagnerDepartment of Nuclear Medicine, Royal Free London NHS Foundation Trust, London, United Kingdom.
Iztok CaglicCentre for Medical Imaging, University College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate staging of renal cell carcinoma (RCC) is critical because small differences in imaging interpretation can alter operative planning, systemic treatment decisions, and prognosis. This educational review highlights the practical role of multimodality imaging in RCC staging, with emphasis on common interpretive pitfalls and reporting strategies that improve clinical decision-making. Contrast-enhanced CT and MRI remain the foundation of local staging, enabling assessment of tumour size, renal sinus and perinephric extension, venous tumour thrombus, and spread beyond the perinephric fascia. However, several features are prone to overcall or undercall, particularly renal sinus invasion, perinephric invasion, inferior vena cava wall involvement, and adjacent organ invasion, with direct implications for management. Regional and distant staging are likewise imperfect. Nodal assessment remains limited by the overlap between reactive enlargement and metastatic disease, while indeterminate pulmonary nodules, marrow-based bone metastases, and atypical metastatic sites may all complicate interpretation. Selected technical considerations, including the potential value of arterial phase imaging in suspected clear cell RCC and the problem-solving role of MRI in equivocal local staging, may help reduce understaging. The role of PET and emerging targeted tracers remains selective rather than routine. Throughout, emphasis is placed on management-relevant imaging findings, modality-specific strengths and weaknesses, and practical pearls derived from experience. A structured reporting approach is also proposed to improve completeness, consistency, and communication with the multidisciplinary team.

Indexed as

Carcinoma, Renal CelloMagnetic Resonance ImagingoMultimodal ImagingoNeoplasm StagingoPositron-Emission TomographyTomography, X-Ray Computedo

Identifiers

PMID42406034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.