ArticleAngewandte Chemie (International ed. in English)2026
Au(III) Complexes as Pyroptosis Inducers by Targeting Mitochondrial DNA for Tumor Immunity.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A photoimmune synergizing RNA interference technology for highly effective antitumor treatment.Smart molecules : open access · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Targeting mitochondrial DNA (mtDNA) to induce a highly inflammatory form of cell death, such as pyroptosis, represents a promising yet underexplored therapeutic strategy. In this study, we report a novel cationic Au(III) Schiff base complex (Au9) that selectively accumulates in mitochondria, targets mtDNA, and induces mtDNA damage. Additionally, Au9 inhibits thioredoxin reductase (TrxR) activity, elevates reactive oxygen species (ROS) levels, and triggers endoplasmic reticulum stress (ERS). These combined effects activate the caspase-3/gasdermin E (GSDME) pathway, leading to pyroptosis. This process is accompanied by the release of damage-associated molecular patterns (DAMPs), significantly enhancing immunogenic cell death (ICD). Further investigations indicate that Au9 effectively modulates the tumor immune microenvironment by promoting dendritic cells (DCs) maturation and CD4
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