Evidence map›Paper›PMID 42405796›Full record

ArticleMicrobiology spectrum2026

Rhein reduces conjugation of IncFII-type plasmids in

Nannan Wang, Haitao Ma, Hanyan Cheng, Xu Yang, Long Liu, Dekang Zhu, Shaqiu Zhang, Xun Zhou, Renyong Jia, Yuanfeng Zou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nannan Wang *Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Haitao Ma *Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Hanyan Cheng *Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Xu YangNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Long LiuNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Dekang ZhuKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, China.ORCID 0000-0002-7314-1088
Shaqiu ZhangKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Xun ZhouNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Renyong JiaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Yuanfeng ZouNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Lixia LiNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Xu SongNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Zhongqiong YinNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.ORCID 0000-0003-1752-644X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance genes (ARGs) can be rapidly disseminated via bacterial conjugation, resulting in a substantial decline in the clinical efficacy of antibiotics. Novel therapeutic strategies independent of conventional antimicrobials are urgently needed. In this study, we identified rhein (RHE), a natural anthraquinone compound, as an effective IncFII plasmid transfer-reducing agent. At sub-inhibitory concentrations, RHE significantly reduced the conjugative transfer of IncFII plasmids in IMPORTANCE: Antimicrobial resistance in bacteria has become an increasingly severe global health challenge. The widespread dissemination of colistin resistance genes has markedly compromised the clinical efficacy of colistin, underscoring an urgent need for novel strategies to limit the spread of resistance determinants. In this study, we investigated the regulatory effects of rhein on IncFII-type plasmids and evaluated its intervention potential in the transmission of the colistin resistance gene

Indexed as

AnthraquinonesAnti-Bacterial AgentsConjugation, GeneticDrug Resistance, BacterialEscherichia coliPlasmidsAnimalsEscherichia coli InfectionsEscherichia coli ProteinsGene Transfer, HorizontalHumansMiceMicrobial Sensitivity TestsQuorum SensingAnthraquinonesAnti-Bacterial AgentsEscherichia coli ProteinsMCR-1 protein, E colirheinBiofilmhorizontal gene transferIncFII plasmidmcr-1Rhein

Identifiers

PMID42405796
PMCPMC13435978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.