Evidence map›Paper›PMID 42405785›Full record

ArticleMicrobiology spectrum2026

Lactylation of its phosphoprotein interferes with the replication of the spring viremia of carp virus.

Yanan Song, Zhi Li, Jun Li, Ziyi Li, Le Yuan, Yanyi Wang, Runkun Yan, Fuxiang Lai, Jing Wang, Wuhan Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yanan SongState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, People's Republic of China.
Zhi LiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, People's Republic of China.
Jun LiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, People's Republic of China.
Ziyi LiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, People's Republic of China.
Le YuanState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, People's Republic of China.
Yanyi WangState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, People's Republic of China.
Runkun YanState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, People's Republic of China.
Fuxiang LaiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, People's Republic of China.
Jing WangState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, People's Republic of China.ORCID 0000-0002-4122-5471
Wuhan XiaoState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, People's Republic of China.ORCID 0000-0002-2978-0616

Funding

National Basic Research Program of China 2024YFD2401104National Natural Science Foundation of China 32473147
6 · The paper itself

Abstract

The metabolic by-product of glycolysis, lactate, and lactylation-mediated protein modification are involved in various biological processes, including host antiviral responses. The spring viremia of carp virus (SVCV), a rhabdovirus that devastates aquaculture, relies on its multifunctional phosphoprotein (P) for replication and evasion of the host immune system. In this study, we found that SVCV infection increased lactate levels in zebrafish, with lactate modulating SVCV proliferation through lactylation of the viral P protein.

Indexed as

Fish DiseasesLactic AcidPhosphoproteinsRhabdoviridaeRhabdoviridae InfectionsViral ProteinsVirus ReplicationAnimalsCarpsProtein Processing, Post-TranslationalZebrafishLactic AcidPhosphoproteinsViral ProteinslactylationldhaphosphoproteinSVCV

Identifiers

PMID42405785
PMCPMC13436216

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.