Evidence map›Paper›PMID 42405595›Full record

ArticleASN neuro2026

Uric Acid Released from Poly (Lactic-co-Glycolic Acid) Nanoparticles Mitigates Glutamate-Induced Excitotoxicity of Spinal Cord Neurons.

Kaavyashri Anbumani, Brandon J Vaglio, Agam Aviv, Courtney M Stains, Katie Lynch, Rene S Schloss, Bonnie L Firestein

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PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaavyashri AnbumaniDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Brandon J VaglioDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Agam AvivDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Courtney M StainsDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Katie LynchDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Rene S SchlossDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Bonnie L FiresteinDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is often compounded by secondary damage caused by glutamate-induced excitotoxicity (GIE), where excessive glutamate release results in neuronal damage by overstimulation of glutamate receptors. This process leads to mitochondrial dysfunction, oxidative stress, and neuronal death. Uric acid (UA) has been identified as a potential neuroprotective molecule due to its antioxidant properties, but its limited solubility poses challenges for clinical use. To address this issue, we encapsulated UA in poly (lactic-co-glycolic acid) nanoparticles (UA-NPs) using a modified double emulsion technique to enhance stability and delivery of UA. Spinal cord cultures were subjected to GIE, followed by treatment with UA-NPs or empty nanoparticles. Neuronal survival was assessed with immunocytochemistry for the neuronal marker microtubule-associated protein 2 (MAP2), which revealed that treatment with UA-NPs resulted in significantly higher cell survival compared to cultures treated with empty nanoparticles. These findings suggest that UA-NPs provide neuroprotection to spinal cord neurons in vitro and may serve as a promising localized drug delivery system for SCI treatment, offering a targeted approach to mitigate secondary injury.

Indexed as

Glutamic AcidLactic AcidNanoparticlesNeuronsNeuroprotective AgentsPolyglycolic AcidSpinal CordUric AcidAnimalsCells, CulturedCell SurvivalMicrotubule-Associated ProteinsPolylactic Acid-Polyglycolic Acid CopolymerRatsRats, Sprague-DawleyGlutamic AcidLactic AcidMicrotubule-Associated ProteinsNeuroprotective AgentsPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerUric AcidGlutamate-induced excitotoxicitynanoparticlesneuronal cultureneuroprotectionspinal cord neuronsuric acid

Identifiers

PMID42405595
PMCPMC13349032

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.