ArticleInfection & chemotherapy2026
Multidrug-Resistant Gram-Negative Bacteremia among Pediatric Oncology Patients with Neutropenic Fever: Associated Risk Factors and Mortality Outcomes.
Article in Infection & chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChildren with cancers remain at a high risk of mortality due to infection, compounded by rising rates of multidrug-resistant Gram-negative bacteria (MDR-GNB), particularly in developing countries. This study aimed to determine the occurrence of bacteremia caused by MDR-GNB and identify the associated risk factors and the clinical outcomes. MATERIALS AND
methodsA retrospective cohort study was conducted using medical records from children with cancers aged 0-18 years at Dr. Sardjito Hospital, a tertiary care center in Indonesia, between 2020 and 2024. Patients with neutropenic fever and bacteremia were enrolled in the analysis. Multivariate logistic regression was used to analyze the associated factors of bacteremia caused by MDR-GNB, while Cox regression analysis was utilized to assess the outcomes of 30-days mortality rate.
resultsA total of 63 cases were included. MDR-GNB was identified in 28.6% (18/63) of patients, representing 52.9% (18/34) of all Gram-negative bacteremia. Most patients had hematologic malignancies (87.2%), with a median absolute neutrophil count (ANC) of 60 cells/mm³ (interquartile range: 0-320). The predominant pathogens were
conclusionChildren with cancers and neutropenic fever should be carefully evaluated for MDR-GNB infection, particularly if the ANC was low and cytostatics were administered within the past week. Comprehensive strategies are essential to mitigate the risks of mortality among pediatric patients with MDR-GNB.
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