Evidence map›Paper›PMID 42405525›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2026

Association of epiretinal membranes with disability in people with multiple sclerosis.

Ting-Yi Lin, Anna Bacchetti, Brenna McCormack, Hussein Moussa, Jonathan D Krett, Omar Ezzedin, Gabriel Otero-Duran, Nicole Pellegrini, Madeline Inserra, Scott D Newsome and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ting-Yi LinDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9605-8095
Anna BacchettiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0000-9434-8531
Brenna McCormackDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0002-6678-7021
Hussein MoussaDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jonathan D KrettDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Omar EzzedinDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gabriel Otero-DuranDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nicole PellegriniDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Madeline InserraDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Scott D NewsomeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bardia NourbakhshDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-6617-2003
Kathryn C FitzgeraldDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-3137-0322
Elias S SotirchosDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8812-1637
Peter A CalabresiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7776-6472
Amir H KashaniDepartment of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins Hospital, Baltimore, MD, USA.
Shiv SaidhaDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6387-0714

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
NINDS NIH HHS R01 NS082347
6 · The paper itself

Abstract

backgroundEpiretinal membranes (ERMs) consist of glial and fibrocellular tissue, potentially arising from pathologic microgliosis, macrogliosis, and/or retinal pigment epithelium (RPE) cell migration. The clinical relevance of ERMs in people with multiple sclerosis (PwMS) remains largely unstudied.

objectivesTo investigate ERM prevalence and their associations with retinal layer thicknesses and disability measures in PwMS.

methodsPwMS exhibiting ERMs (ERM+) were matched 1:1 with PwMS without ERMs (ERM-) by optic neuritis (ON) history, multiple sclerosis (MS) subtype, age, sex, and race. Disability assessments included high-contrast/low-contrast letter acuity (HC-/LCLA), Expanded Disability Status Scale (EDSS), walking speed test (WST), manual dexterity test (MDT), and processing speed test (PST) scores.

resultsAmong 1264 participants screened (1120 PwMS and 144 healthy controls [HCs]), ERMs were observed in 206 PwMS (18.4%) and 17 HCs (11.8%). ERM+ PwMS exhibited higher EDSS (1.0 ± 0.3,

conclusionERMs may identify a distinct MS phenotype, potentially characterized by pathological microglial and/or macroglial activity. ERMs may be a marker of similar global processes throughout the central nervous system that potentially contribute to greater overall disability.

Indexed as

Epiretinal membranemultiple sclerosisoptical coherence tomography

Identifiers

PMID42405525
PMCPMC13339839

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.