ArticleVeterinary dermatology2026
Cutaneous Reactive Histiocytosis in Golden Retrievers: An Immunohistochemical Approach.
Article in Veterinary dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Cutaneous Reactive Histiocytosis in Golden Retrievers: An Immunohistochemical Approach.Veterinary dermatology · 2026Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCanine cutaneous reactive histiocytosis (CRH) is a proliferative histiocytic disease characterised by the accumulation of dendritic cells (DCs). Differentiating CRH from other infectious or non-infectious granulomatous or histiocyte-rich diseases is challenging on histological evidence alone. HYPOTHESIS/
objectivesThis study aims to characterise the predominant histiocytic population in 11 golden retrievers with histological features compatible with CRH, using ionised calcium-binding adapter molecule 1 (Iba1) and a validated macrophage antibodies cocktail for canine skin diseases. ANIMALS: Eleven golden retriever dogs were enrolled with a clinical and histological diagnosis of CRH. MATERIALS AND
methodsParaffin-embedded skin biopsy samples from cases with a confirmed diagnosis of CRH were evaluated to identify the histiocytic cell type. Two antibody reagents were used: (1) anti-Iba1 (goat polyclonal), a broad histiocytic marker and (2) a cocktail of rabbit recombinant monoclonal antibodies against CD11b, CD68, CD163, CD14 and CD16 to phenotype cutaneous macrophages.
resultsAll cases showed positive immunostaining with both antibodies. Although Iba1 immunostaining was diffuse in most of the histiocytoid cell population, only a few scattered histiocytoid cells stained with the anti-macrophage antibody cocktail. CONCLUSION AND CLINICAL RELEVANCE: Strong Iba1 positivity in the histiocytoid cells, together with their lack of staining for macrophage markers, supports a dendritic cell phenotype and is consistent with a diagnosis of CRH. In conclusion, using a macrophage marker in combination with a broad histiocytic marker may help to distinguish CRH from granulomatous, macrophage-rich diseases in paraffin-embedded skin tissue.
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