ArticleMolecular therapy. Nucleic acids2026
A DNA-guided prokaryotic argonaute enables programmable RNA cleavage for sequencing and quality control of
Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Argonaute (Ago) endonucleases are ubiquitous across all domains of life and, like Cas nucleases, can be programmed by guide oligonucleotides to target and cleave specific nucleic acid sequences. However, unlike Cas enzymes, Agos are not restricted by sequence requirements such as protospacer adjacent motifs (PAMs), enhancing their utility as molecular tools. This study demonstrates diverse applications of the DNA-guided RNA endonuclease
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