Evidence map›Paper›PMID 42405254›Full record

ArticlePeerJ2026

A retrospective study of differential prognostic factors in early-onset

Lifang Huang, Runtao Zhong, Kangkang Li, Jinfeng Chen, Yunxian He, Yuanning Ye, Shuxian Chen, Qili Wei, Huizhen Mai, Yali Zhang and 1 more

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In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Lifang Huang *Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Runtao Zhong *Department of Health Management, Zengcheng Central Hospital, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Kangkang LiDepartment of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jinfeng ChenDepartment of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yunxian HeDepartment of Gastroenterology, Zengcheng Central Hospital, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yuanning YeDepartment of Gastroenterology, Zengcheng Branch of Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Shuxian ChenDepartment of Gastroenterology, Zengcheng Branch of Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Qili WeiDepartment of Gastroenterology, Zengcheng Branch of Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Huizhen MaiDepartment of Gastroenterology, Zengcheng Branch of Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yali ZhangDepartment of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhiqing WangDepartment of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The incidence of early-onset colorectal cancer (EO-CRC; age <50 years) has been increasing worldwide. This single-center retrospective study aimed to compare the clinical characteristics of EO-CRC and late-onset CRC (LO-CRC; age ≥ 50 years) and to identify age-specific prognostic factors for overall survival (OS). Methods: A total of 1,148 CRC patients were retrospectively analyzed and categorized into EO-CRC ( Results: EO-CRC patients showed higher proportions of family history, concurrent polyps, and Programmed Cell Death Ligand 1 (PD-L1) expression >10%, whereas LO-CRC patients exhibited higher rates of hypertension, diabetes, and elevated carcinoembryonic antigen (CEA) levels. Although OS did not differ significantly between groups ( Conclusion: This study suggests that EO-CRC and LO-CRC have fundamentally different prognostic determinants: the former emphasizes genetic susceptibility and tumor invasiveness, indicating that this group of patients may benefit from early genetic counseling, MMR/MSI testing, and immune checkpoint inhibitor therapy. The latter highlights age, acquired molecular changes, and chronic systemic factors, supporting the inclusion of metabolic and geriatric assessments in routine tumor care.

Indexed as

Colorectal NeoplasmsMachine LearningAdultAgedAge of OnsetFemaleHumansMaleMiddle AgedPrognosisRandom ForestRetrospective StudiesROC CurveEarly-onset colorectal cancerLASSO regressionLate-onset colorectal cancerMachine learningOverall survivalPrognostic factorsRandom survival forest

Identifiers

PMID42405254
PMCPMC13332719

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.