ReviewPeerJ2026
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas genome editing transforming crop stress tolerance for global food security.
Review in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Climate change increasingly threatens global crop productivity by intensifying drought, salinity, temperature extremes, and biotic stresses. Developing climate-resilient cultivars has therefore become a central objective in modern crop breeding programs. Conventional breeding approaches are often limited by complex trait inheritance and long selection cycles, particularly for polygenic stress-adaptive traits. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein (Cas) genome editing genome editing provides a precise and efficient platform for targeted manipulation of genes controlling stress tolerance, yield stability, and adaptive performance. This review synthesizes recent advances in CRISPR mediated improvement of resilience to major abiotic stresses (drought, salinity, heat, and cold) and biotic stresses (fungi, bacteria, viruses, and insects) across important cereal, legume, and horticultural crops. Emphasis is placed on the editing of transcription factors, signaling regulators, susceptibility genes, and redox-associated pathways that enhance physiological and molecular stress adaptation. Furthermore, the integration of CRISPR with genomics, transcriptomics, proteomics, metabolomics, genome-wide association studies, high-throughput phenotyping, and artificial intelligence-driven prediction tools is accelerating precision breeding strategies. Despite remaining challenges related to off-target effects, delivery systems, and regulatory frameworks, genome editing represents a transformative approach for advancing climate-resilient crop development and sustainable agricultural production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.