ArticleRSC advances2026
High-efficiency isolation of fetal nucleated red blood cells for non-invasive prenatal diagnosis
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Non-invasive prenatal diagnosis (NIPD) utilizing fetal nucleated red blood cells (fNRBCs) holds great promise for comprehensive genetic analysis; however, its clinical application is challenged by the extreme rarity of these cells in maternal peripheral blood. Herein, we present a two-step cascaded microfluidic platform designed for the high-efficiency isolation of fNRBCs. This integrated system employs a deterministic lateral displacement (DLD) microfluidic chip for the initial label-free enrichment of large cells, including fNRBCs, based on size. The enriched product is subsequently subjected to negative purification using a magnetic microfluidic chip, where residual white blood cells are depleted following incubation with CD45-coated magnetic beads. Using spiked K562 cells as a model, the device demonstrated a consistently high recovery efficiency exceeding 90%. In a clinical validation with 20 maternal blood samples, fNRBCs (identified as DAPI
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