ArticleRSC advances2026
A deep eutectic solvent mediated synthesis of spiro[naphthalene-2,5'-pyrimidine]-4-carbonitriles and their
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A green and efficient deep eutectic solvent (DES)-mediated multicomponent strategy has been developed for the synthesis of spiro[naphthalene-2,5'-pyrimidine]-4-carbonitriles. This protocol utilizes a biodegradable choline chloride/urea (1 : 2) DES as a sustainable reaction medium, and offers a good yield of targeted products (67-93%), broad substrate scope and high atom economy, while eliminating volatile organic solvents and harsh conditions. The DES can be easily recovered and reused for multiple cycles with minimal loss of efficiency. With operational simplicity, straightforward isolation and excellent recyclability, this approach offers practical and environmental benign multicomponent synthesis of spiro[naphthalene-2,5'-pyrimidine]-4-carbonitriles. The synthesized compounds were also docked and molecular dynamics (MD) simulations was performed to investigate the binding affinity, molecular interactions and stability of our synthesized spiro[naphthalene-2,5'-pyrimidine]-4-carbonitriles with the amino acids of coronavirus main protease (6LU7). All the compounds were found to be potent in comparison with reference inhibitor, remdesivir (-6.62 kcal mol
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