ArticleRSC advances2026
Development of a green design reverse phase liquid chromatography method for determining the ionization profile of parabens.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The most popular method for determining chromatographic separation selectivity is an optimization method based on the use of different solvents. This article presents a sustainable chromatographic framework using reverse phase liquid chromatography (RPLC) to determine the ionization behavior of methylparaben, ethylparaben, propylparaben, and butylparaben, which are widely used in hydroorganic mixtures. In this study, retention-mobile phase pH data in methanol-water (40-55% v/v) and ethanol-water (30-45% v/v) mixtures were analyzed using a nonlinear regression (NLREG) approach to calculate the dissociation constant values of the compounds. Simultaneously, solvent strength selectivity was determined by varying the percentage of organic solvent in the mobile phase. Experimental studies were performed at 37 °C using a Gemini NX column (250 × 4.60 mm I.D., 3.5 µm). The solvatochromic solvent polarity parameter (
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