Evidence map›Paper›PMID 42404994›Full record

ArticleNPJ dementia2026

Common and rare variant analyses implicate

Tamil Iniyan Gunasekaran, Devendra Meena, Annie J Lee, Siwei Wu, Logan Dumitrescu, Reisa Sperling, Timothy J Hohman, Jingxian Huang, A4 Study, Alzheimer’s Disease Sequencing Project (ADSP) and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tamil Iniyan GunasekaranThe Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY USA.
Devendra MeenaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Annie J LeeDepartment of Neurology, College of Physicians and Surgeons, Columbia University and the New York Presbyterian Hospital, New York, NY USA.
Siwei WuDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Logan DumitrescuVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN USA.
Reisa SperlingDepartment of Neurology, Massachusetts General Hospital, Boston, MA USA.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN USA.
Jingxian HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
A4 Study
Alzheimer’s Disease Sequencing Project (ADSP)
Abbas DehghanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Richard MayeuxThe Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY USA.
Badri VardarajanThe Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY USA.

Funding

Genetic Association Between Alzheimer's Disease and Cardio-Cerebrovascular Risk FactorsK01AG084849 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Annie J Lee · 2024 to 2026
$377k
NIA NIH HHS K01 AG084849
6 · The paper itself

Abstract

Genetic research on Alzheimer's disease (AD) has primarily focused on amyloid-β (Aβ), with fewer studies exploring tau pathology. We performed common variant GWAS on tau-PET SUVRs from A4 (

Indexed as

DiseasesGeneticsNeurologyNeuroscience

Identifiers

PMID42404994
PMCPMC13331746

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.