SynthesisFrontiers in public health2026
Global prevalence and biopsychosocial correlates of psychological distress among people living with HIV: an updated theory-informed meta-analysis.
Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Introduction: Psychological distress (PD) is common among people living with HIV (PLWH), but prevalence estimates vary substantially. This study aimed to synthesize the prevalence of PD among PLWH and examine its heterogeneity and associated factors. Methods: Following PRISMA 2020, we systematically searched seven electronic databases from inception to June 20, 2025, for observational studies on PD prevalence and associated factors among PLWH. PD was operationalized as a binary outcome using validated self-report instruments with explicit cut-offs. The pooled prevalence was estimated using a generalized linear mixed model, and associated factors were synthesized as pooled ORs. Subgroup analyses and univariable meta-regression were performed to explore heterogeneity. Study quality was assessed, and the certainty of evidence was rated using the Grading of Recommendations Assessment, Development and Evaluation framework. Results: Sixteen studies (10,204 PLWH) were included. The pooled prevalence of PD was 0.40 (95% CI: 0.28-0.53), with considerable heterogeneity ( Conclusion: PD is a common burden among PLWH, and this review provides an updated evidence base to identify vulnerable populations, refine measurement, and inform care priorities, though findings should be interpreted cautiously due to considerable heterogeneity and low to very low certainty of evidence. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251089847, identifier (CRD420251089847).
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