SynthesisFrontiers in immunology2026
Transplacental transfer of anti-malarial antibodies: a systematic review.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pregnant women and young children bear the highest burden of malaria morbidity/mortality. While transplacental transfer of malaria antibodies protects the child, the efficiency varies by antigen and maternal factors. This systematic review assessed transplacental transfer of malaria antibodies, factors associated with reduced transfer and identified knowledge gaps for future research. Method: We searched PubMed, Scopus, Web of Science and HINARI from the inception of databases until January 2025. We included published articles reporting anti-malaria antibodies in the mother and newborn, placental transfer and factors associated with reduced transplacental transfer of antibodies against malaria antigen. Two independent reviewers conducted the selection of articles, data extraction and risk of bias assessment. Meta-analyses of malaria prevalence were performed on the peripheral blood of mothers, on the placenta, and on the cord blood of newborns. Result: Forty-two studies (n=8687 pregnant women and newborns) were included in the analysis. Twelve studies reported the prevalence of malaria among mothers detected peripherally, 13 for placental malaria, and five studies for newborns. The pooled prevalence of peripheral and placental malaria was found to be 31.27% (95%CI: 24.9, 38.45), and 30.65% (95%CI: 20.29, 43.43), respectively. The pooled prevalence of malaria in the newborn was 9.53% (95%CI: 4.18, 20.29). IgG1 and IgG3 against malaria antigen were the predominant IgG that placentally transferred efficiently. IgG against circumsporozoite protein was more transferred to the newborn than those against the merozoite surface protein 3. Factors such as HIV infection, placental malaria, hypergammaglobulinemia in mothers, low birth weight, and primigravida were associated with reduced maternal transfer of antibodies against malaria antigen to newborns. Conclusion: Maternal transfer of antibodies against malaria antigen to newborns was IgG subclass and antigen-dependent. Vaccination strategies promoting high potential of transplacental transfer in pregnant women may enhance child protection against severe malaria. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024609217, identifier CRD42024609217.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.