Evidence map›Paper›PMID 42404830›Full record

ReviewStroke (Hoboken, N.J.)2026

Beyond the Catheter: Contemporary Aspiration Pump Systems in Neurointerventional Stroke Therapy.

Sai Sanikommu, Connor Berger, Alejandro N Santos, Caleigh Roach, Victor M Lu, Emade Jaman, Sima M Vazquez, Ahmed Abdelsalam, Romil Singh, Tiffany Eatz and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stroke (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sai SanikommuDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.ORCID https://orcid.org/0009-0006-3637-5033
Connor BergerDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.ORCID https://orcid.org/0000-0003-3126-6672
Alejandro N SantosDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.ORCID https://orcid.org/0000-0002-6616-5313
Caleigh RoachDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.ORCID https://orcid.org/0009-0005-1577-2112
Victor M LuDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.
Emade JamanDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.
Sima M VazquezDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.
Ahmed AbdelsalamDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.ORCID https://orcid.org/0000-0001-6651-9030
Romil SinghDepartment of Neurosurgery, AHN Health Network, Philadelphia, PA (R.S., E.L.).
Tiffany EatzDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.ORCID https://orcid.org/0000-0003-3861-8335
Ali MortezaeiStudent Research Committee, Gonabad University of Medical Sciences, Iran (A.M.).ORCID https://orcid.org/0000-0002-7217-3264
Alick P WangDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.ORCID https://orcid.org/0000-0003-2641-8205
Evan LutherDepartment of Neurosurgery, AHN Health Network, Philadelphia, PA (R.S., E.L.).ORCID https://orcid.org/0000-0001-9164-4984
John W ThompsonDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.
Christopher P KellnerDepartment of Neurosurgery, Mount Sinai Hospital, NY (C.P.K.).ORCID https://orcid.org/0000-0003-4604-8205
Robert M StarkeDepartment of Neurological Surgery (S.S., C.B., A.N.S., C.R., V.M.L., E.J., S.M.V., A.A., T.E., A.P.W., J.W.T., R.M.S.), University of Miami School of Medicine, FL.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute ischemic stroke is the greatest cause of morbidity and mortality among cerebrovascular pathologies. Over time, several therapeutic options have been developed for treating patients with stroke, including IV r-tPA (intravenous recombinant tissue-type plasminogen activator) and IV-TNK (intravenous tenecteplase) thrombolysis, and endovascular mechanical thrombectomy, with the latter showing favorable recanalization rates. Stent retrievers and mechanical aspiration, the 2 types of mechanical thrombectomy, are used for acute ischemic stroke due to large-vessel occlusions. The first reported aspiration thrombectomy dates back to 2002, during which a 50 mL syringe was used to generate negative pressure and aspirate a clot. Since then, extensive research and development have transformed aspiration thrombectomy. Penumbra's first system paved the way for present-day aspiration systems in neurointerventional surgery, such as the Penumbra engine and Thunderbolt aspiration systems. Ongoing innovations have focused on improving access to challenging vascular locations and enabling the removal of large thrombi. Over time, aspiration techniques have also evolved. However, despite successful first-pass complete revascularization, a subset of patients continues to experience poor functional outcomes, highlighting the multifactorial nature of stroke recovery. In this review, we outline in detail the historical development of aspiration pump systems in neuroendovascular surgery, describe the different systems and their technical characteristics, highlight the clinical trials evaluating their efficacy, with particular attention to distinctions between devices, and discuss avenues for future growth.

Indexed as

acute ischemic strokecathetersembolismthrombectomythrombolytic therapy

Identifiers

PMID42404830
PMCPMC13331443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.