Evidence map›Paper›PMID 42404770›Full record

ReviewFrontiers in cellular and infection microbiology2026

Gut microbiota as a therapeutic target in sepsis-induced multi-organ dysfunction: a review.

Xinlan Zhao, Tiangang Ma, Jinyan Yu, Yanbing Hu

Abstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xinlan ZhaoDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
Tiangang MaDepartment of Ultrasound Medicine Department, The Second Hospital of Jilin University, Changchun, Jilin, China.
Jinyan YuDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
Yanbing HuDepartment of Ultrasound Medicine Department, The Second Hospital of Jilin University, Changchun, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis and the resulting multiple organ dysfunction carry a high mortality rate, and effective treatment remains lacking owing to the condition's heterogeneity. The translocation of gut microbiota plays an essential role in the occurrence and development of sepsis and organ dysfunction. Uncontrolled inflammatory responses in sepsis, together with antibiotic use during treatment, lead to gut microbiota translocation. This in turn promotes sepsis progression and organ dysfunction by altering microbial metabolite production and causing immune dysregulation. Drawing on literature from databases such as PubMed and Web of Science, this review summarizes the interactions between intestinal microbiota translocation, sepsis, and organ dysfunction, aiming to identify new targets for the prevention and treatment of sepsis.

Indexed as

Gastrointestinal MicrobiomeMultiple Organ FailureSepsisAnimalsAnti-Bacterial AgentsBacterial TranslocationHumansIntestinal Barrier FunctionAnti-Bacterial Agentsgut microbiotainflammatory responsesintestinal barrier disruptionmulti-organ dysfunctionorgan damage

Identifiers

PMID42404770
PMCPMC13328463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.