ArticleFrontiers in cellular and infection microbiology2026
Skin microbiome characterization in acne vulgaris across urban and rural Egyptian populations.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Objective: To characterize the skin microbiome associated with acne vulgaris in Egyptian urban and rural populations and assess the influence of acne severity and lifestyle factors on microbial diversity. Methods: We recruited 45 acne patients (urban n=37, rural n=8) and 25 healthy urban controls. Skin swabs were collected and analyzed by 16S rRNA sequencing. Microbial community profiles were generated with QIIME2, while differential taxa and functional pathways were evaluated using ANCOM-BC and PICRUSt2. Results: In urban patients, moderate-to-severe acne was associated with greater microbial evenness and diversity, though species richness was unchanged. Community composition differed significantly by severity. Functional analysis revealed enrichment of amino acid biosynthesis pathways. Rural patients showed greater diversity, distinct microbial structures, and functional enrichment in amino acid and lipid metabolism pathways, with reduced enrichment in energy metabolism pathways. A depletion of Conclusion: Interventions that selectively eliminate pathogenic
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