Evidence map›Paper›PMID 42404637›Full record

ArticleCase reports in oncology

Congenital Acute Lymphoblastic Leukaemia with Hyperleucocytosis in a Full-Term Neonate: A Case Report.

Rasha Ebraheem, Amjad Mohammad Bashir Soudan, Ibraheem Ali Al Ali, Nader Eid

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rasha EbraheemDepartment of Pediatrics, University Pediatrics Hospital, Damascus University, Damascus, Syria.
Amjad Mohammad Bashir SoudanFaculty of Medicine, Damascus University, Damascus, Syria.
Ibraheem Ali Al AliFaculty of Medicine, Damascus University, Damascus, Syria.
Nader EidDepartment of Pediatrics, University Pediatrics Hospital, Damascus University, Damascus, Syria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Congenital leukaemia is a rare neonatal malignancy (<1% of childhood leukaemias) that often presents with nonspecific signs such as hepatosplenomegaly, skin lesions, and haematological abnormalities, making diagnosis challenging. Case Presentation: We report a 25-day-old full-term female neonate with fever, multiple subcutaneous nodules, bruising, petechiae, and hepatosplenomegaly. Laboratory investigations demonstrated extreme hyperleukocytosis, severe anaemia, thrombocytopenia, elevated lactate dehydrogenase, and hyperuricaemia. Peripheral blood smear revealed numerous lymphoblasts. Flow cytometry confirmed B-cell precursor acute lymphoblastic leukaemia. The patient received supportive care and was subsequently referred for chemotherapy. However, she died shortly after transfer. Conclusion: Congenital leukaemia should be considered in neonates with unexplained hepatosplenomegaly, skin lesions, pallor, and marked leucocytosis. Early peripheral blood smear evaluation and immunophenotyping are essential.

Indexed as

B-cell precursorCase reportCongenital leukaemiaHyperleukocytosisImmunophenotypingNeonatal acute lymphoblastic leukaemia

Identifiers

PMID42404637
PMCPMC13331472

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