Evidence map›Paper›PMID 42404627›Full record

ArticleMaterials today. Bio2026

Inorganic materials to prevent liquefactive necrosis and improve wound healing: A role of infection control across ischemic models.

Ayden Watt, Benjamin Dalisson, Nitin Chandra Teja Dadi, Sze Wai Lau, Dongyue Xie, Huaifa Zhang, Hani Shash, Ramón Eduardo Núñez Peña, Michael Tanzer, Adam Hart and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ayden WattDivision of Surgical and Interventional Sciences, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, H3G 1A4, Canada.
Benjamin DalissonFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, H3A 1G1, Canada.
Nitin Chandra Teja DadiDivision of Surgical and Interventional Sciences, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, H3G 1A4, Canada.
Sze Wai LauDivision of Surgical and Interventional Sciences, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, H3G 1A4, Canada.
Dongyue XieDivision of Surgical and Interventional Sciences, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, H3G 1A4, Canada.
Huaifa ZhangFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, H3A 1G1, Canada.
Hani ShashDivision of Surgical and Interventional Sciences, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, H3G 1A4, Canada.
Ramón Eduardo Núñez PeñaFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, H3A 1G1, Canada.
Michael TanzerDivision of Orthopaedics, Department of Surgery, Research Institute of the McGill University Health Centre, Montreal, QC, H3G 1A4, Canada.
Adam HartDivision of Orthopaedics, Department of Surgery, Research Institute of the McGill University Health Centre, Montreal, QC, H3G 1A4, Canada.
Gregory BerryDivision of Orthopaedics, Department of Surgery, Research Institute of the McGill University Health Centre, Montreal, QC, H3G 1A4, Canada.
Charlotte JalouxDivision of Plastic and Reconstructive Surgery, Department of Surgery, Research Institute of the McGill University Health Centre, Montreal, QC, H3G 1A4, Canada.
Joshua VorstenboschDivision of Plastic and Reconstructive Surgery, Department of Surgery, Research Institute of the McGill University Health Centre, Montreal, QC, H3G 1A4, Canada.
Kevin WattersDepartment of Pathology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, H3A 2B4, Canada.
Ed HarveyDivision of Orthopaedics, Department of Surgery, Research Institute of the McGill University Health Centre, Montreal, QC, H3G 1A4, Canada.
Nicholas MakhoulFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, H3A 1G1, Canada.
Mirko GilardinoDivision of Plastic and Reconstructive Surgery, Department of Surgery, Research Institute of the McGill University Health Centre, Montreal, QC, H3G 1A4, Canada.
Jake BarraletDivision of Surgical and Interventional Sciences, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, H3G 1A4, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquefactive necrosis, clinically manifesting as wet gangrene, is a catastrophic complication of ischemic wounds driven by bacterial overgrowth, proteolytic tissue lysis, and loss of structural integrity; current treatments remain largely limited to surgical debridement or amputation. Here, we show that inorganic biomaterial films releasing hydroxide ions, with or without oxygen and hydrogen peroxide, can markedly inhibit the development and spread of liquefactive necrosis in ischemic skin and cartilage. A calcium peroxide (CaO

Indexed as

BiomaterialGangreneInorganicIschemiaNecrosisWound

Identifiers

PMID42404627
PMCPMC13332115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.