Evidence map›Paper›PMID 42404575›Full record

ArticleFrontiers in medicine2026

Alterations in T lymphocyte subsets and mitochondrial-related parameters in patients with chronic kidney disease.

Sizeng Bao, Chunlei Luo, Hanlu Wang, Jianwei Ma, Xueyan Bian

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Sizeng BaoDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Chunlei LuoDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Hanlu WangDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Jianwei MaDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Xueyan BianDepartment of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: To investigate the association between renal function and T lymphocyte subsets and mitochondrial-related parameters in patients with chronic kidney disease (CKD). Methods: This retrospective study included patients with CKD between July 2023 and June 2024. Disease stage was assessed based on estimated glomerular filtration rate (eGFR), and patients were classified into CKD stages 1-5 accordingly. Peripheral blood samples were analyzed by flow cytometry to assess T lymphocyte subsets and mitochondrial-related parameters, including mitochondrial mass (MM) and the percentage of cells with low mitochondrial membrane potential (MMP-Low%). Results: A total of 802 patients with CKD were included (440 males; mean age 56.3 ± 16.0 years), comprising 226 stage 1, 204 stage 2, 205 stage 3, 82 stage 4, and 85 stage 5 cases. Lymphocyte percentage was lower and neutrophil percentage higher in stage 5 vs. stages 1-2 (both Conclusion: Reduced T lymphocyte counts and alterations in mitochondrial-related parameters, particularly membrane potential-related parameters, were observed in patients with CKD and were associated with more advanced CKD stages.

Indexed as

chronic kidney diseaseCKDmitochondrial massmitochondrial membrane potentialT lymphocyte subsets

Identifiers

PMID42404575
PMCPMC13327998

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