Successful intravenous alteplase for acute ischemic stroke secondary to radiation-induced intracranial arterial stenosis in a child: An illustrative case.

Takahito Mitsui, Toru Kurokawa, Kohei Suzuki, Junkoh Yamamoto, Yuko Tanaka

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In one paragraph

Article in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Takahito MitsuiDepartment of Neurosurgery and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan.

Toru KurokawaDepartment of Stroke Medicine and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan.

Kohei SuzukiDepartment of Neurosurgery and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan.

Junkoh YamamotoDepartment of Neurosurgery and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan.

Yuko TanakaDepartment of Stroke Medicine and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Delayed cerebrovascular complications after radiotherapy have been well-documented. However, optimal management of acute ischemic stroke secondary to radiation-induced intracranial arterial stenosis remains unclear. Case Description: A 17-year-old girl developed an acute ischemic stroke secondary to delayed middle cerebral artery stenosis following radiotherapy for recurrent craniopharyngioma after tumor resection. Intravenous alteplase (rt-PA) was administered 4 h after symptom onset, resulting in neurological improvement, and she was discharged with a modified Rankin Scale score of 0. Conclusion: This case suggests that rt-PA may be an effective treatment option for acute ischemic stroke associated with post-radiotherapy arterial stenosis, provided that the standard eligibility criteria are met.

Indexed as

Acute ischemic strokeIntravenous alteplasePediatric strokeRadiation-induced intracranial stenosisWatershed infarction

Identifiers

PMID42404468

DOI10.25259/SNI_389_2026

PMCPMC13331182

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LicenceCC BY-NC-SA

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.