ArticleSurgical neurology international2026
Synchronous glioblastoma and pituitary adenoma: Coincidence or shared genetic predisposition? A case report and comprehensive literature review.
Article in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The synchronous occurrence of pathologically distinct primary intracranial tumors is an exceptionally rare clinical entity. The coexistence of an isocitrate dehydrogenase (IDH)-wild-type glioblastoma (GBM) and a pituitary adenoma poses significant diagnostic and therapeutic challenges, with only six previously reported cases in the medical literature; seven, including the present patient. Case Description: We report a 45-year-old man who presented with progressive visual decline and headache. Magnetic resonance imaging demonstrated two separate, distinct lesions: A sellar mass consistent with a pituitary macroadenoma and a left frontal intra-axial lesion suspicious for high-grade glioma. The patient underwent staged surgical management consisting of an endoscopic endonasal transsphenoidal resection of the sellar lesion, followed by a frontal craniotomy for the intra-axial mass. Histopathological examination confirmed a pituitary transcription factor 1-lineage densely granulated lactotroph adenoma (pituitary neuroendocrine tumor) and an IDH-wildtype GBM (World Health Organization grade 4). Adjuvant radiotherapy and temozolomide chemotherapy were administered. GBM recurrence was detected 12 months after surgery, and the patient died 20 months after the initial diagnosis. Conclusion: The coexistence of GBM and pituitary adenoma is exceedingly rare. Including the present patient, only seven cases have been reported to date. Further clinical and molecular investigations are required to clarify whether this association represents a coincidental occurrence or reflects an underlying biological relationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.