ArticleRegenerative biomaterials2026
Bioengineered nasal septum implant with 3D-printed silicone and chondrocyte-seeded fibrin hydrogel.
Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Nasal septum reconstruction remains a significant challenge when native cartilage is deficient due to trauma, congenital defects or oncological resection. Although autologous cartilage grafts remain the gold standard, their use is limited by donor site morbidity and tissue availability. Synthetic implants, while readily available, present rejection, infection and extrusion issues, which complicate their use in nasal reconstruction. Here, we present a bioengineered alternative, that is a hybrid nasal septum implant consisting of a 3D-printed medical-grade silicone scaffold combined with fibrin hydrogels seeded with human nasal chondrocytes (HNCs). HNCs cultured within the fibrin-silicone constructs under chondrogenic conditions (with BMP-2, insulin and triiodothyronine) exhibited robust re-differentiation, evidenced by an upregulated expression of cartilage-specific genes (
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