Evidence map›Paper›PMID 42404410›Full record

ArticleRegenerative biomaterials2026

ROS scavenging nanoengineered bioactive glass interfaces reprogram macrophage immunity for tendon-bone regeneration.

Bowen Cai, Fanrui Zeng, Kaixiao Xue, Zhi Shen, Chang Qiao, Han Wu, Qunyi Wang, Jue Zhang, Shahin Homaeigohar, Kai Zheng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bowen CaiDepartment of Orthopedics, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Fanrui ZengJiangsu Province Engineering Research Center of Stomatological Translational Medicine & Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China.
Kaixiao XueDepartment of Orthopedics, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Zhi ShenDepartment of Orthopedics, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Chang QiaoDepartment of Orthopedics, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Han WuJiangsu Province Engineering Research Center of Stomatological Translational Medicine & Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China.
Qunyi WangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing 210029, China.
Jue ZhangAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu 241002, China.
Shahin HomaeigoharSchool of Science and Engineering, University of Dundee, Dundee DD1 4HN, UK.
Kai ZhengJiangsu Province Engineering Research Center of Stomatological Translational Medicine & Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China.ORCID https://orcid.org/0000-0002-2573-6677
Bin ZhuDepartment of Orthopedics, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Jiahu FangDepartment of Orthopedics, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Failure of rotator cuff repair largely stems from ineffective regeneration of the tendon-bone interface (TBI), driven by persistent inflammation and excessive reactive oxygen species (ROS) accumulation at the biomaterial tissue interface. Here, we engineer an immunoregulatory suture interface by incorporating cerium-doped mesoporous bioactive glass nanoparticles (Ce-MBGNs) into a gelatin/tannic acid (Gel/TA) coating on polyethylene terephthalate sutures. The hierarchical Gel/TA/Ce-MBGN coating displays uniform morphology, robust adhesion and superior ROS scavenging activity.

Indexed as

cerium-doped bioactive glass nanoparticlesimmunomodulationmacrophage polarizationrotator cuff repairsurface modificationtendon–bone interface

Identifiers

PMID42404410
PMCPMC13332430

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.